Description

D-Proline, 4-Hydroxy-2-Methyl-, cis- (9Ci) is a non-proteinogenic, chiral proline derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a critical chiral building block and intermediate for the development of novel active pharmaceutical ingredients (APIs) and complex bioactive molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for applications requiring high stereochemical purity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of complex drug candidates, particularly for protease inhibitors and other biologically active compounds.
• Peptidomimetics Research: Used to construct modified peptide backbones to enhance metabolic stability, bioavailability, and receptor selectivity in drug discovery.
• Asymmetric Catalysis: Employed as a precursor or ligand component in the development of chiral catalysts for stereoselective transformations.
• Agrochemical Synthesis: Serves as an intermediate in the production of advanced, enantiomerically pure pesticides and herbicides.
• Biochemical Research: Utilized in studies of enzyme mechanisms and as a probe for understanding proline metabolism and its role in biological systems.
• Fine Chemical Production: A valuable starting material for the custom synthesis of specialty chemicals and advanced materials requiring specific stereochemistry.

Basic Information

Product Name	D-Proline, 4-Hydroxy-2-Methyl-, cis- (9Ci)
CAS No.	152722-92-4
Molecular Formula	C6H11NO3
Molecular Weight	145.16 g/mol
Synonyms	(2S,4R)-4-Hydroxy-2-methylpyrrolidine-2-carboxylic acid; cis-4-Hydroxy-D-2-methylproline; D-cis-4-Hydroxy-2-methylproline; (2S,4R)-4-Hydroxy-2-methylproline; 4-Hydroxy-2-methyl-D-proline; 152722-92-4; (4R)-4-Hydroxy-(2S)-2-methyl-L-proline (D-configuration); L-Proline, 4-hydroxy-2-methyl-, (2S,4R)- (rel)
EINECS	Contact for details

Quality Control

Our D-Proline, 4-Hydroxy-2-Methyl-, cis- (9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.