Description

Farnesyl Pyrophosphate-[1-3H(N)] Triammonium Salt is a high-specific-activity, tritium-labeled biochemical essential for studying isoprenoid biosynthesis and protein prenylation. This radiolabeled compound serves as a critical tracer in enzymatic assays, enabling precise quantification and mechanistic investigation of farnesyltransferase and geranylgeranyltransferase activity. It is primarily utilized by researchers and process developers in pharmaceutical R&D, biotechnology, and academic institutions focused on cancer, metabolic disorders, and infectious disease pathways.

Application

• Enzymology Research: As a radiolabeled substrate for in vitro assays of farnesyl pyrophosphate synthase (FPPS), farnesyltransferase (FTase), and geranylgeranyltransferase (GGTase).
• Drug Discovery & Screening: High-throughput screening (HTS) of inhibitors targeting the mevalonate pathway for the development of anticancer, anti-parasitic, and bone disorder therapeutics.
• Metabolic Pathway Analysis: Tracing the incorporation of isoprenoid units into downstream products like dolichols, ubiquinone, and heme A in cell-based studies.
• Protein Prenylation Studies: Investigating the post-translational modification of Ras-family GTPases and other signaling proteins to understand oncogenesis and cell regulation.
• Biochemical Standard: Use as a quantitative standard in LC-MS or radiometric detection methods for metabolic profiling.
• Academic Research: Fundamental studies on terpenoid and sterol biosynthesis in plants, microbes, and mammals.

Basic Information

Product Name	Farnesyl Pyrophosphate-[1-3H(N)] Triammonium Salt
CAS No.	152558-65-1
Molecular Formula	C15H28O7P2 • 3H3N
Molecular Weight	Approx. 463.3 g/mol (unlabeled salt)
Synonyms	FPP-[1-3H(N)]; [1-3H]Farnesyl Pyrophosphate Triammonium Salt; Tritiated FPP; (3H)Farnesyl Diphosphate; All-trans-Farnesyl Diphosphate-[1-3H]; Isoprenoid Pyrophosphate Tracer; (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-yl trihydrogen diphosphate-[1-3H] triammonium salt
EINECS	Contact for details

Quality Control

Every batch of our radiolabeled biochemicals is manufactured and controlled under strict quality systems to ensure high radiochemical purity and specific activity. Product integrity is verified via analytical techniques including HPLC with radiometric detection. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specific activity, purity, solvent composition, and analytical chromatograms. Our production adheres to guidelines suitable for research use in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store frozen at or below -20°C in the original solvent as supplied. This product is hygroscopic (moisture-sensitive). For long-term stability, avoid repeated freeze-thaw cycles and store under inert atmosphere when aliquoting.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (HPLC)	Conforms to reference standard
Specific Activity	15-25 Ci/mmol (Contact for exact value)
Radiochemical Purity (HPLC)	≥ 95%
Chemical Purity (HPLC)	≥ 90%
Concentration	1 mCi/mL (approx. 0.05-0.1 mM in buffer/ethanol)
Solvent System	Aqueous buffer / Ethanol (specific ratio per batch)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.