Description

Oxycodone-D6 is a deuterium-labeled analog of the potent semi-synthetic opioid analgesic, oxycodone. This stable isotope-labeled compound is an essential reference standard and internal standard for precise quantitative analysis in pharmaceutical research and forensic toxicology. It is primarily used by analytical laboratories, forensic science institutions, and pharmaceutical R&D departments engaged in method development, pharmacokinetic studies, and drug metabolism research.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering internal standard for the accurate quantification of oxycodone and its metabolites in biological matrices (e.g., plasma, urine) using liquid chromatography-tandem mass spectrometry.
• Pharmaceutical Research & Development: Used in method development and validation for drug potency assays, stability testing, and impurity profiling of oxycodone-based pharmaceutical formulations.
• Forensic Toxicology & Clinical Analysis: Enables precise measurement of oxycodone concentrations in post-mortem and human performance testing, supporting legal and medical determinations.
• Pharmacokinetic & Metabolic Studies: Facilitates the tracking and quantification of oxycodone absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Reference Material for Calibration: Acts as a certified reference material (CRM) to calibrate analytical instruments and ensure the accuracy and traceability of test results.
• Quality Control in Manufacturing: Employed in the in-process and final product testing of oxycodone active pharmaceutical ingredients (APIs) and finished dosage forms to verify identity and purity.

Basic Information

Product Name	Oxycodone-D6
CAS No.	152477-91-3
Molecular Formula	C18H15D6NO4
Molecular Weight	321.38 g/mol
Synonyms	14-Hydroxydihydrocodeinone-D6; Dihydrohydroxycodeinone-D6; Oxycodone-d6 (hexadeuterated); 4,5α-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one-D6; (5R,9R,13S,14R)-4,5α-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one-D6; Deuterated Oxycodone; Oxycodone (hexadeuterated)
EINECS	Contact for details

Quality Control

Our Oxycodone-D6 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR and mass spectrometry for isotopic enrichment verification and HPLC for chemical and isotopic purity. We provide Certificates of Analysis (COA) detailing batch-specific results for identity, assay, and impurity profiles. Our quality commitment ensures material suitable for use as a reference standard in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or CoA. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 98.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.