Description

(-)-Epibatidine-L-Tartrate CAS NO 152378-30-8 is a high-purity, enantiomerically pure salt form of the potent alkaloid epibatidine. This compound is of significant value as a selective and high-affinity ligand for nicotinic acetylcholine receptors (nAChRs), making it a critical research tool in neuroscience and pharmacology. It is primarily required by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in neurobiological studies, receptor characterization, and the development of novel analgesics or neurological therapeutics.

Application

• Neuroscience Research: As a potent and selective agonist for neuronal nicotinic acetylcholine receptors (nAChRs) for studying receptor function and signaling pathways.
• Pharmacological Studies: Used in in vitro and in vivo models to investigate pain mechanisms and the development of non-opioid analgesic agents.
• Receptor Binding Assays: A key reference standard and radioligand in competitive binding experiments to screen and characterize new nAChR-targeting compounds.
• Biochemical Tool Compound: Employed in structural biology studies, including X-ray crystallography and molecular modeling, to understand ligand-receptor interactions.
• Toxicology & Safety Pharmacology: Used to study the effects of nAChR activation and to establish safety profiles for related drug candidates.

Basic Information

Product Name	(-)-Epibatidine-L-Tartrate
CAS No.	152378-30-8
Molecular Formula	C18H24N2O6
Molecular Weight	364.40 g/mol
Synonyms	(-)-Epibatidine L-Tartrate Salt; (1R,2R,4S)-2-(6-Chloro-3-pyridyl)-7-azabicyclo[2.2.1]heptane L-Tartrate; Epibatidine (-)-Isomer Tartrate; exo-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1]heptane (1R,2R,4S)-L-Tartrate; ABT-418 Tartrate (related analog); nAChR Agonist (-)-Epibatidine Tartrate
EINECS	Contact for details

Quality Control

Our (-)-Epibatidine-L-Tartrate is manufactured under strict quality control protocols to ensure the highest standards of purity and enantiomeric excess for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and residual solvent levels. We adhere to cGMP principles where applicable for research-grade materials to guarantee batch-to-batch consistency and reliable performance in sensitive assays.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccant and under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.