Description

Sb 203580 is a potent and selective cell-permeable inhibitor of p38 MAP kinase, a key signaling protein involved in cellular stress responses. This compound is crucial for research into inflammatory pathways, apoptosis, and cell cycle regulation. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in drug discovery and molecular biology studies. Sb 203580 CAS NO 152121-47-6 serves as an essential tool compound for elucidating the role of p38 MAPK in various disease models.

Application

• Biochemical Research: Used as a selective inhibitor to study the p38 mitogen-activated protein kinase (MAPK) signaling pathway in vitro.
• Drug Discovery & Development: A key pharmacological tool for validating p38 MAPK as a therapeutic target in inflammatory diseases, cancer, and neurodegenerative disorders.
• Cell Biology Studies: Employed to investigate the role of p38 in cellular processes such as apoptosis, cytokine production, and cell differentiation.
• Academic Research: Utilized in university and institutional labs for fundamental research on signal transduction mechanisms.
• Inflammation Modeling: Applied in research models to understand and modulate inflammatory responses at the molecular level.
• High-Throughput Screening (HTS): May serve as a reference compound or control in screening assays designed to identify novel p38 inhibitors.

Basic Information

Product Name	Sb 203580
CAS No.	152121-47-6
Molecular Formula	C16H14FN3O2S
Molecular Weight	331.36 g/mol
Synonyms	4-[4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine; SB 203580; SB203580; SB-203580; p38 MAP Kinase Inhibitor III; SKF-86002; 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole
EINECS	Contact for details

Quality Control

Our Sb 203580 is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency suitable for research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity determination and NMR for structural confirmation. A detailed Certificate of Analysis (COA) documenting identity, purity, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.