Description

Tosylthreonylglycine Methyl Ester is a protected amino acid derivative, specifically a tosylated threonine-glycine dipeptide methyl ester. This compound is a crucial building block in peptide synthesis, offering precise control over molecular structure and reactivity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Peptide Synthesis Intermediate: A key protected fragment for the solid-phase or solution-phase synthesis of complex peptide sequences.
• Pharmaceutical Research: Used in the R&D of therapeutic peptides targeting various diseases, including metabolic disorders and oncology.
• Bioconjugation Chemistry: Serves as a precursor for creating peptide-based conjugates for drug delivery systems or diagnostic probes.
• Biochemical Tool Development: Employed in the design and production of enzyme substrates, inhibitors, or affinity ligands for proteomic studies.
• Academic Research: Fundamental studies in organic chemistry, medicinal chemistry, and biochemistry exploring peptide structure-activity relationships.
• Custom Synthesis: A starting material for the bespoke production of specialized peptides and fine chemicals for industrial clients.

Basic Information

Product Name	Tosylthreonylglycine Methyl Ester
CAS No.	151656-28-9
Molecular Formula	C16H24N2O7S
Molecular Weight	388.44 g/mol
Synonyms	N-[(p-Toluenesulfonyl)-L-threonyl]glycine methyl ester; L-Threonine, N-[(4-methylphenyl)sulfonyl]-, glycyl-, methyl ester; Tos-Thr-Gly-OMe; Tos-Thr-Gly methyl ester; N-Tosyl-L-threonylglycine methyl ester; Methyl N-(N-tosyl-L-threonyl)glycinate; Tosyl-Thr-Gly-OMe; Protected Thr-Gly dipeptide methyl ester
EINECS	Contact for details

Quality Control

Our Tosylthreonylglycine Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.