Description

2-C-Methyl-D-Erythritol 1,2-Cyclophosphate 4-Phosphate is a key phosphorylated intermediate in the non-mevalonate (MEP/DOXP) pathway for isoprenoid biosynthesis. This compound matters significantly for research and development in metabolic engineering and the targeted inhibition of essential biological pathways in pathogens. It is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and biotechnology sectors for use as a biochemical tool, a reference standard, or a potential precursor in synthetic biology applications.

Application

• Biochemical Research: Critical intermediate for studying the MEP/DOXP pathway in bacteria, apicomplexan parasites (e.g., *Plasmodium*), and plant plastids.
• Drug Discovery: Target molecule for the development of novel antibiotics, antimalarials, and herbicides that selectively inhibit the essential isoprenoid biosynthesis in pathogens.
• Enzyme Kinetics & Inhibition Studies: Used as a substrate or inhibitor for enzymes like IspF (2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase) within the pathway.
• Metabolic Engineering: A building block or reference point for engineering microbial strains for the enhanced production of isoprenoids, such as terpenes.
• Diagnostic & Analytical Standards: Serves as a high-purity reference standard for LC-MS, HPLC, or NMR analysis in metabolic profiling.
• Academic & Institutional Research: Fundamental tool for universities and research institutes exploring bacterial metabolism and novel antimicrobial strategies.

Basic Information

Product Name	2-C-Methyl-D-Erythritol 1,2-Cyclophosphate 4-Phosphate
CAS No.	151435-51-7
Molecular Formula	C5H12O10P2
Molecular Weight	294.09 g/mol
Synonyms	2-C-Methyl-D-erythritol 2,4-cyclodiphosphate 2-phosphate; MEcPP 2-phosphate; 2-C-Methyl-D-erythritol 2,4-cyclopyrophosphate 2-phosphate; 2-C-Methylerythritol 1,2-cyclophosphate 4-phosphate; (3R)-3-[(1R)-1-[(3S)-3,4-Dihydroxy-2-oxo-2λ5,4λ5-dioxa-1,3,2λ5,4λ5-diphosphapentan-1-yl]oxyethyl]-2,2-dihydroxy-3,4-dihydro-2H-1,2λ5-oxaphosphol-3-ol 2-oxide; MECP 2-phosphate; Intermediate of the MEP pathway; IspF substrate analog
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with research-grade standards. Identity, purity, and impurity profiles are verified using advanced analytical techniques including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption and decomposition. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.