Description

1,2-Dioleoyl-Sn-Glycero-3-Phosphomethanol (Sodium Salt) is a high-purity synthetic phospholipid derivative, a critical component for advanced formulation science. Its primary value lies in its unique amphiphilic structure, making it an essential building block for creating stable, functional lipid-based delivery systems. This compound is particularly vital for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced material sectors who require precise and reliable lipid excipients for next-generation applications.

Application

• Lipid Nanoparticle (LNP) Formulation: A key structural lipid for the development of mRNA, siRNA, and other nucleic acid delivery vehicles.
• Liposome & Niosome Preparation: Used as a functionalized phospholipid to create targeted and stealth liposomal drug carriers for cancer therapy and diagnostics.
• Biomimetic Membrane Research: Serves as a model phospholipid in studies of membrane biophysics, protein-lipid interactions, and cell membrane mimicry.
• Surface Modification & Coatings: Employed to create biocompatible and functional surfaces on medical devices and implants due to its phosphomethanol head group.
• Stabilizer for Emulsions & Dispersions: Acts as a high-performance emulsifier and stabilizer in complex cosmetic and pharmaceutical nanoemulsions.
• Gene Therapy Vector Development: A critical raw material in the formulation of non-viral vectors for gene editing and therapeutic gene delivery.

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phosphomethanol (Sodium Salt)
CAS No.	151379-99-6
Molecular Formula	C42H78NaO9P
Molecular Weight	781.02 g/mol
Synonyms	DOPM (Na Salt); 1,2-Dioleoyl-sn-glycero-3-phospho(methanol); (2R)-2,3-Bis[[(Z)-octadec-9-enoyl]oxy]propyl (hydroxymethyl) phosphate sodium salt; Phosphatidylmethanol, sodium salt; Sodium 1,2-dioleoyl-sn-glycero-3-phosphomethanol; Methanol phospholipid sodium salt; PM-Na; Lipid 151379-99-6
EINECS	Contact for details

Quality Control

Our 1,2-Dioleoyl-Sn-Glycero-3-Phosphomethanol (Sodium Salt) is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) detailing purity, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white waxy solid or film
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Solvent Residues (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%
Phosphorus Content	Conforms to theoretical
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.