Description

4,5-Didehydro Brimonidine is a key pharmaceutical intermediate and a derivative of the active pharmaceutical ingredient brimonidine. This compound matters for its role in the research and development of novel ophthalmic and neurological treatments, offering a pathway to new therapeutic agents. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and drug discovery programs.

Application

• Critical intermediate in the synthesis of brimonidine and its novel analogs for pharmaceutical development.
• Research chemical for studying α-2 adrenergic receptor agonists and their mechanisms of action.
• Building block in medicinal chemistry for creating new chemical entities (NCEs) targeting glaucoma and other intraocular pressure disorders.
• Reference standard in analytical method development and quality control for brimonidine-based drug products.
• Precursor for the development of prodrugs with enhanced ocular bioavailability.
• Starting material for the synthesis of isotopically labeled compounds (e.g., deuterated brimonidine) for pharmacokinetic and metabolic studies.

Basic Information

Item	Details
Product Name	4,5-Didehydro Brimonidine
CAS No.	151110-15-5
Molecular Formula	C11BrN5
Molecular Weight	286.09 g/mol
Synonyms	5-Bromo-6-(4,5-dihydro-1H-imidazol-2-ylamino)quinoxaline; 2-[(5-Bromoquinoxalin-6-yl)amino]-4,5-dihydro-1H-imidazole; Brimonidine Impurity; Brimonidine Related Compound; UK-14,304-18; Alphagan Impurity; AGN 190342 Impurity; Quinoxaline derivative UK-14,304 analog
EINECS	Contact for details

Quality Control

Our 4,5-Didehydro Brimonidine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity. A detailed Certificate of Analysis (COA) confirming batch-specific results is provided with every shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.