Description

Brinzolamide Hydrochloride CAS NO 150937-43-2 is a high-purity, non-bacteriostatic sulfonamide derivative that acts as a potent and selective carbonic anhydrase II inhibitor. This compound is of critical importance in the development and manufacturing of ophthalmic pharmaceutical formulations. It is primarily required by pharmaceutical companies and research institutions engaged in the production of intraocular pressure-lowering medications for the treatment of glaucoma and ocular hypertension.

Application

• Active Pharmaceutical Ingredient (API) in ophthalmic solutions and suspensions for glaucoma therapy.
• Key intermediate in the synthesis of novel carbonic anhydrase inhibitors for pharmaceutical research.
• Reference standard for quality control and analytical method development in pharmaceutical laboratories.
• Biochemical research tool for studying carbonic anhydrase enzyme kinetics and inhibition mechanisms.
• Formulation development for combination drug products targeting ocular diseases.
• Pre-clinical and clinical trial material for new drug development programs.

Basic Information

Item	Detail
Product Name	Brinzolamide Hydrochloride
CAS No.	150937-43-2
Molecular Formula	C12H21N3O5S3 • HCl
Molecular Weight	432.96 g/mol
Synonyms	Brinzolamide HCl; (R)-(+)-4-Ethylamino-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride; Azopt (brand name active); AL-4862; AL 4862; BRL 48962; BRL-48962; 5-(4-Ethylamino-2-methoxy-3,4-dioxo-1-cyclobuten-1-yl)-2-thiophenesulfonamide hydrochloride
EINECS	Contact for details

Quality Control

Our Brinzolamide Hydrochloride is manufactured under strict quality systems suitable for pharmaceutical applications. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting or exceeding relevant pharmacopeial standards. A detailed Certificate of Analysis (COA) documenting purity, related substances, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	[α]20/D: +15.0° to +18.0° (c=1 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.