Description

(6R,S)-5,6,7,8-Tetrahydrofolic Acid (Hydrochloride) is a reduced form of folic acid, serving as a critical biochemical intermediate in one-carbon metabolism. This compound is essential for research and development in pharmaceutical synthesis, particularly for creating novel folate analogs and investigating metabolic pathways. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of high-purity biochemical reagents.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the synthesis of advanced folate-based drugs and targeted therapies.
• Biochemical Research: Used as a standard or substrate in enzymatic studies related to folate metabolism, methylation cycles, and nucleotide biosynthesis.
• Nutritional Science Studies: Employed in *in vitro* research to study the bioavailability and metabolic fate of reduced folate forms.
• Reference Standard: Serves as a high-purity analytical reference standard for quality control in pharmaceutical manufacturing.
• Cell Culture Media Supplement: Potential component in specialized cell culture formulations requiring specific folate sources.

Basic Information

Item	Details
Product Name	(6R,S)-5,6,7,8-Tetrahydrofolic Acid (Hydrochloride)
CAS No.	150731-85-4
Molecular Formula	C19H23N7O6 • HCl
Molecular Weight	497.90 g/mol (for free base C19H23N7O6)
Synonyms	5,6,7,8-Tetrahydrofolic Acid Hydrochloride; (6R,S)-H4Folate HCl; Tetrahydrofolate HCl; (6R,S)-5,6,7,8-Tetrahydrofolate Hydrochloride; (6R,S)-5,6,7,8-Tetrahydrofolic Acid HCl; (6R,S)-H4PteGlu HCl; (6R,S)-Tetrahydrofolate Monohydrochloride; (6R,S)-5,6,7,8-Tetrahydrofolate Monohydrochloride
EINECS	Contact for details

Quality Control

Our (6R,S)-5,6,7,8-Tetrahydrofolic Acid (Hydrochloride) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets rigorous standards suitable for research and development applications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. For long-term stability, the product should be kept in a desiccator to protect from moisture. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.