Description

8-Azidoguanosine Diphosphate-Mannose is a chemically modified nucleotide sugar derivative, specifically designed as a metabolic probe and biochemical tool. This compound is critical for researchers studying glycosylation pathways, glycan biosynthesis, and carbohydrate-protein interactions. It is primarily utilized in the life sciences sector for advanced biochemical research, metabolic labeling, and the development of novel diagnostic and therapeutic agents.

Application

• Metabolic Labeling and Glycan Profiling: Used as a bioorthogonal chemical reporter to label and track newly synthesized glycans in living cells.
• Enzymatic Activity Assays: Serves as a substrate or inhibitor in assays for glycosyltransferases and other enzymes involved in nucleotide sugar metabolism.
• Chemical Biology and Proteomics: Enables the identification and characterization of glycan-binding proteins through affinity-based pull-down or cross-linking experiments.
• Glycoconjugate Synthesis: Acts as a key intermediate in the chemoenzymatic synthesis of azide-tagged oligosaccharides and glycoconjugates for downstream click chemistry applications.
• Drug Discovery Research: Employed in target validation and screening platforms for diseases where glycosylation is dysregulated, such as cancer and immune disorders.
• Diagnostic Development: Used in the creation of novel diagnostic tools that exploit specific glycan-lectin interactions.

Basic Information

Product Name	8-Azidoguanosine Diphosphate-Mannose
CAS No.	150518-46-0
Molecular Formula	C16H23N8O16P2
Molecular Weight	645.35 g/mol
Synonyms	8-Azido-GDP-mannose; GDP-8-azidoguanosine-mannose; 8-N3-GDP-Man; Guanosine 5'-(trihydrogen diphosphate), P'-→5'-ester with 8-azidoguanosine, 2'-(dihydrogen phosphate) 3'→5'-ester with D-mannose; 8-Azido-guanosine diphosphomannose; Azido-GDP-mannose
EINECS	Contact for details

Quality Control

Our 8-Azidoguanosine Diphosphate-Mannose is produced under stringent quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term stability, store under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.