Description

Fmoc-Cys(Mob)-Opfp is a specialized, activated ester derivative of the amino acid cysteine, protected with Fmoc and Mob groups. This compound is a critical building block for the solid-phase synthesis of peptides and peptidomimetics, offering high coupling efficiency and minimal racemization. It is an essential reagent for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing therapeutic peptides, diagnostic probes, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary reagent for the efficient, sequential incorporation of cysteine residues into peptide chains using Fmoc-chemistry protocols.
• Peptidomimetic & Conjugate Development: Enables the synthesis of peptide-based drug candidates, protein mimics, and antibody-drug conjugates (ADCs) requiring site-specific cysteine modification.
• Combinatorial Chemistry Libraries: Used in high-throughput synthesis to create diverse libraries of cysteine-containing compounds for drug discovery screening.
• Bioconjugation & Labeling: Facilitates the controlled attachment of fluorophores, biotin, or other functional groups to peptides and proteins via the reactive thiol group after deprotection.
• Research & Process Development: Serves as a key intermediate in academic and industrial R&D for studying protein structure-function relationships and developing new synthetic methodologies.

Basic Information

Product Name	Fmoc-Cys(Mob)-Opfp
CAS No.	150372-68-2
Molecular Formula	C₂₆H₂₀F₅NO₅S
Molecular Weight	553.50 g/mol
Synonyms	Fmoc-Cys(Mob)-OPfp; Fmoc-S-(4-Methoxybenzyl)-L-cysteine pentafluorophenyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-(4-methoxybenzyl)-L-cysteine 2,3,4,5,6-pentafluorophenyl ester; Fmoc-Cysteine(Mob)-OPfp ester; Fmoc-L-Cys(Mob)-OPfp; Nα-Fmoc-S-(4-methoxybenzyl)-L-cysteine pentafluorophenyl ester; Fmoc-Cys(4-MeOBzl)-OPfp; Fmoc-Cys(Mob)-O-Pfp
EINECS	Contact for details

Quality Control

Our Fmoc-Cys(Mob)-Opfp is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive peptide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines for active pharmaceutical ingredients (APIs) and advanced intermediates, ensuring compliance for pre-clinical and clinical-stage development.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C. This product is hygroscopic (moisture-sensitive) and should be handled under a dry, inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.