Description

Nicotinamide Ribose 5'-o-(S-(3-Bromo-2-Oxopropyl))Thiophosphate is a specialized biochemical intermediate of significant interest in advanced research and pharmaceutical development. This compound is valued for its role as a key precursor in the synthesis of novel NAD+ analogs and other bioactive molecules, enabling critical studies in cellular metabolism and signaling pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on metabolic research, enzyme studies, and the development of next-generation therapeutics.

Application

• Pharmaceutical Research & Development: Serves as a critical synthetic intermediate for creating novel NAD+ precursors and modulators for metabolic disorder research.
• Biochemical Tool Compound: Used in enzymatic studies and as a probe to investigate sirtuin and PARP enzyme activity and regulation.
• Precision Synthesis: Employed in the custom synthesis of labeled compounds (e.g., isotopically labeled) for tracer studies and metabolic flux analysis.
• Academic Research: Facilitates fundamental studies in cell biology, aging, and energy metabolism within university and institutional laboratories.
• Fine Chemical Intermediate: Used in the multi-step synthesis of high-value, complex active pharmaceutical ingredients (APIs) and diagnostic agents.

Basic Information

Product Name	Nicotinamide Ribose 5'-o-(S-(3-Bromo-2-Oxopropyl))Thiophosphate
CAS No.	150035-59-9
Molecular Formula	C14H21BrN3O9PS
Molecular Weight	518.27 g/mol
Synonyms	NR-5'-Thiophosphate Bromoacetone Derivative; 3-Bromo-2-oxopropyl 5-O-Phosphonothio-β-D-ribofuranosyl Nicotinamide; 5'-O-[S-(3-Bromo-2-oxopropyl)]thiophosphonic Acid Adenosine Ester; Nicotinamide Riboside 5'-Thiophosphate Activated Ester; β-Nicotinamide Ribose Monophosphate (3-Bromo-2-oxopropyl) Thioester; CAS 150035-59-9
EINECS	Contact for details

Quality Control

Our Nicotinamide Ribose 5'-o-(S-(3-Bromo-2-Oxopropyl))Thiophosphate is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.