Description

(4S,4As,5Ar,12As)-9-Amino-4,7-Bis(Dimethylamino)-1,4,4A,5,5A,6,11,12A-Octahydro-3,10,12,12A-Tetrahydroxy-1,11-Dioxo-2-Naphthacenecarboxamide Sulfate is a high-purity, complex tetracycline derivative salt, valued for its specific stereochemistry and functional groups. This compound is critical for advanced pharmaceutical research and development, particularly in the synthesis of novel antibiotic agents and the study of structure-activity relationships. It serves as a key pharmaceutical intermediate for researchers and manufacturers in the life sciences sector requiring precise molecular building blocks.

Application

• Pharmaceutical Intermediate: A key starting material or intermediate in the synthesis of novel tetracycline-class antibiotics and other therapeutic agents.
• Antibiotic Research & Development: Used in medicinal chemistry programs to explore new derivatives with improved efficacy against resistant bacterial strains.
• Biochemical Research: Serves as a reference standard or probe in studies investigating bacterial protein synthesis inhibition mechanisms.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the controlled, multi-step synthesis of complex active drug substances under Good Manufacturing Practice (GMP) conditions.
• Academic & Institutional Research: Utilized in university and institutional labs for chemical biology and pharmacology studies.
• Process Development & Scale-Up: Supports process chemistry teams in developing and optimizing scalable synthetic routes for new drug candidates.

Basic Information

Item	Details
Product Name	(4S,4As,5Ar,12As)-9-Amino-4,7-Bis(Dimethylamino)-1,4,4A,5,5A,6,11,12A-Octahydro-3,10,12,12A-Tetrahydroxy-1,11-Dioxo-2-Naphthacenecarboxamide Sulfate
CAS No.	149934-20-3
Molecular Formula	C₂₅H₃₂N₄O₁₀S
Molecular Weight	580.61 g/mol
Synonyms	9-Amino-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide sulfate; Tetracycline derivative sulfate salt; (4S,4aS,5aR,12aS)-9-Amino-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-naphthacenecarboxamide sulfate; 2-Naphthacenecarboxamide, 9-amino-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, sulfate (1:1); Modified Tetracycline Intermediate Sulfate
EINECS	Contact for details

Quality Control

Our (4S,4As,5Ar,12As)-9-Amino-4,7-Bis(Dimethylamino)-1,4,4A,5,5A,6,11,12A-Octahydro-3,10,12,12A-Tetrahydroxy-1,11-Dioxo-2-Naphthacenecarboxamide Sulfate is manufactured and controlled under a rigorous quality management system. Each batch is tested using advanced analytical techniques (HPLC, NMR, MS) to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We can support development projects requiring material compliant with ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccated or inert atmosphere packaging.

Specification

Item	Specification
Appearance	Yellow to orange-yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 5.0% Any single impurity ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.