Description

Palonosetron is a highly potent and selective second-generation 5-HT₃ receptor antagonist. This compound is valued for its superior efficacy and extended duration of action in preventing nausea and vomiting. It is a critical active pharmaceutical ingredient (API) primarily required by pharmaceutical manufacturers in the oncology and surgical sectors for the formulation of injectable and oral antiemetic medications.

Application

• Primary Pharmaceutical API: Manufacture of injectable solutions for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV).
• Oral Formulation Development: Key ingredient in the production of tablet or capsule forms for post-operative nausea and vomiting (PONV) prevention.
• Oncology Supportive Care: Essential component in combination therapy regimens to manage emesis following highly emetogenic chemotherapy.
• Clinical Research: Used as a reference standard or active compound in pharmacological studies and new drug development projects.
• Generic Drug Production: Sourcing of high-purity API for the formulation of bioequivalent generic antiemetic drugs.
• Veterinary Medicine: Potential application in veterinary oncology for managing chemotherapy-related side effects in animals.

Basic Information

Product Name	Palonosetron
CAS No.	149653-99-6
Molecular Formula	C19H24N2O
Molecular Weight	296.41 g/mol
Synonyms	Palonosetron Hydrochloride; (3aS)-2-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one; RS-25259-197; Aloxi® (Brand Name); Onicit; Paloxi; Palosetron
EINECS	Contact for details

Quality Control

Our Palonosetron is manufactured under strict quality management systems. We provide material that meets or exceeds relevant pharmacopeial standards, including USP and ICH guidelines. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles to ensure regulatory compliance and batch-to-batch consistency for our global pharmaceutical clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.