Description

2-Fluorooctanoyl-Coenzyme A is a specialized fluorinated analog of octanoyl-CoA, a critical intermediate in fatty acid metabolism. This compound is primarily utilized as a potent and selective inhibitor of fatty acid oxidation and as a biochemical tool to study metabolic pathways, particularly in mitochondrial β-oxidation. Researchers in pharmaceutical development, metabolic disease research, and enzymology require this high-purity biochemical for investigating lipid metabolism, enzyme kinetics, and developing therapeutic strategies for conditions like cancer and cardiac ischemia.

Application

• Biochemical Research: Used as a mechanism-based inhibitor to study the enzymes of mitochondrial β-oxidation, such as medium-chain acyl-CoA dehydrogenase (MCAD).
• Metabolic Pathway Analysis: A key tool for probing fatty acid metabolism in cell cultures, tissue homogenates, and isolated organelles to understand energy homeostasis.
• Pharmaceutical Development: Serves as a reference standard and investigative compound in drug discovery programs targeting metabolic disorders, including heart disease and certain cancers.
• Enzyme Kinetics Studies: Employed to determine inhibition constants (Ki) and elucidate the catalytic mechanisms of acyl-CoA dehydrogenases and related enzymes.
• Diagnostic Assay Development: Can be used in the development of in vitro diagnostic tests for inherited metabolic diseases related to fatty acid oxidation defects.

Basic Information

Product Name	2-Fluorooctanoyl-Coenzyme A
CAS No.	149542-22-3
Molecular Formula	C29H48FN7O17P3S
Molecular Weight	910.69 g/mol
Synonyms	2-Fluorooctanoyl-CoA; 2-Fluoro-octanoyl-coenzyme A; Coenzyme A, S-[2-fluorooctanoyl]-; 2-Fluorocapryloyl-Coenzyme A; S-(2-Fluorooctanoyl)coenzyme A; Fluorooctanoyl-CoA; 2-F-O-CoA; Inhibitor of Fatty Acid Oxidation
EINECS	Contact for details

Quality Control

Our 2-Fluorooctanoyl-Coenzyme A is manufactured under stringent conditions to ensure high biochemical purity and activity, suitable for sensitive research applications. Each batch is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and biological activity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Enzymatic)	≥ 90% (by acyl-CoA dehydrogenase inhibition)
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.