Description

n-(4-(2-(2,4-Diamino-6,7-Dihydro-5H-Cyclopenta(D)Pyrimidin-5-Yl)Ethyl)Benzoyl)Glutamic Acid CAS NO 149325-93-9 is a high-purity, non-classical folate analog and a key pharmaceutical intermediate. This compound is critical for the research and development of novel antifolate drugs, which target specific metabolic pathways in rapidly dividing cells. It is primarily required by pharmaceutical R&D laboratories and manufacturers specializing in oncology and autoimmune disease therapeutics.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of advanced antifolate drugs and targeted therapies.
• Oncology Research: Used in the development of novel chemotherapeutic agents that inhibit dihydrofolate reductase (DHFR) and other folate-dependent enzymes.
• Biochemical Research: Serves as a reference standard and tool compound for studying folate metabolism and transport mechanisms in cellular systems.
• Antimicrobial Agent Development: Investigated for its potential in creating new antibiotics that target bacterial folate synthesis.
• Autoimmune Disease Therapeutics: Applied in the research of treatments for conditions like rheumatoid arthritis and psoriasis, where antifolates are used as disease-modifying agents.
• Precision Medicine: Supports the development of personalized medicine approaches by enabling the synthesis of targeted molecular entities.

Basic Information

Item	Information
Product Name	n-(4-(2-(2,4-Diamino-6,7-Dihydro-5H-Cyclopenta(D)Pyrimidin-5-Yl)Ethyl)Benzoyl)Glutamic Acid
CAS No.	149325-93-9
Molecular Formula	C21H25N7O5
Molecular Weight	455.47 g/mol
Synonyms	5-[2-[4-[(2,4-Diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidin-5-yl)methyl]benzoyl]amino]pentanedioic acid; CB 300638; (S)-2-((4-((2,4-Diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidin-5-yl)methyl)benzamido)pentanedioic acid; Non-classical folate analog; Cyclopenta[d]pyrimidine glutamic acid derivative; Antifolate intermediate; GARFT inhibitor intermediate
EINECS	Contact for details

Quality Control

Our n-(4-(2-(2,4-Diamino-6,7-Dihydro-5H-Cyclopenta(D)Pyrimidin-5-Yl)Ethyl)Benzoyl)Glutamic Acid is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with each batch, detailing all critical quality attributes. We adhere to cGMP principles for pharmaceutical intermediates to support our clients' regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.