Description

Dorzolamide CAS NO 149249-72-9 is a potent and selective carbonic anhydrase inhibitor, primarily used as an active pharmaceutical ingredient (API). Its core value lies in its ability to effectively reduce intraocular pressure, making it a critical component in ophthalmic solutions. This compound is essential for pharmaceutical manufacturers developing treatments for conditions such as glaucoma and ocular hypertension. We supply high-purity Dorzolamide to meet the stringent demands of the global pharmaceutical industry.

Application

• Ophthalmic Pharmaceutical Formulations: Primary use as the key API in prescription eye drops for glaucoma management.
• Combination Therapies: Used in fixed-dose combination products with other agents like timolol for enhanced therapeutic efficacy.
• Research & Development: Serves as a reference standard and a key intermediate in pharmacological research targeting carbonic anhydrase enzymes.
• Drug Substance Manufacturing: Supplied as a bulk active ingredient for final dosage form production under cGMP conditions.
• Veterinary Ophthalmology: Potential application in developing treatments for ocular pressure disorders in animals.

Basic Information

Product Name	Dorzolamide
CAS No.	149249-72-9
Molecular Formula	C10H16N2O4S3
Molecular Weight	324.39 g/mol
Synonyms	(4S,6S)-4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide; L-671,152; MK-0507; Trusopt (Brand Name); Dorzolamide Hydrochloride; Dorzolamide HCl; (S,S)-Dorzolamide
EINECS	Contact for details

Quality Control

Our Dorzolamide is manufactured and tested to meet the highest pharmacopeial standards, including USP and EP monographs. Every batch undergoes rigorous analytical testing for identity, purity, potency, and specified impurities. We provide comprehensive Certificates of Analysis (COA) that detail all test results against release specifications, ensuring full traceability and compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	NMT 1.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm
Related Substances (HPLC)	Total impurities NMT 1.0% Any individual impurity NMT 0.5%
Optical Rotation	Specific range provided on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.