Description

11-Dehydro-2,3-Dinor-Thromboxane B2 is a stable metabolite of thromboxane B2, a key eicosanoid involved in platelet aggregation and vascular function. This compound serves as a critical biomarker and reference standard for research into cardiovascular diseases, inflammation, and related metabolic pathways. It is essential for pharmaceutical R&D, clinical diagnostics, and academic laboratories focused on eicosanoid biology and drug discovery.

Application

• Biomarker Analysis: Used as a quantitative reference standard in LC-MS/MS and ELISA assays to measure thromboxane metabolite levels in biological samples (e.g., urine, plasma) for clinical research.
• Pharmaceutical R&D: Serves as a key intermediate and analytical standard in the development and testing of anti-thrombotic and anti-inflammatory drugs.
• Metabolic Pathway Studies: Employed in biochemical research to investigate the arachidonic acid cascade, thromboxane synthesis, and related eicosanoid pathways.
• Diagnostic Kit Manufacturing: Integral component in the calibration and validation of commercial diagnostic kits for cardiovascular risk assessment.
• Quality Control & Method Validation: Used as a certified reference material (CRM) to validate analytical methods in compliance with GLP and ISO 17025 standards.

Basic Information

Product Name	11-Dehydro-2,3-Dinor-Thromboxane B2
CAS No.	148682-73-9
Molecular Formula	C₁₈H₂₈O₆
Molecular Weight	340.4 g/mol
Synonyms	11-Dehydro-2,3-dinor-TXB2; 11-Dehydro-thromboxane B2 metabolite; DH-TXB2; 11-Dehydro-2,3-dinor-thromboxane B2; 2,3-Dinor-11-dehydro-thromboxane B2; TXB2-M; Thromboxane B2 metabolite; 11-Dehydro-2,3-dinor-TXB2
EINECS	Contact for details

Quality Control

Our 11-Dehydro-2,3-Dinor-Thromboxane B2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for research and diagnostic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and compliance with GLP practices.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 2.0%
Solubility	Soluble in ethanol, methanol; slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.