Description

Nonyl-β-D-1-Thiomaltoside is a high-purity, non-ionic detergent and surfactant belonging to the alkyl thioglycoside family. This specialized compound is valued for its ability to solubilize and stabilize membrane proteins without denaturing them, making it a critical reagent in structural biology and biochemistry. It is essential for research and development in the pharmaceutical and biotechnology sectors, particularly for applications involving protein crystallization and purification.

Application

• Membrane Protein Solubilization: Primary application for extracting and stabilizing integral membrane proteins for structural and functional studies.
• Protein Crystallization: Used as a detergent in crystallization screens to facilitate the formation of high-quality protein crystals for X-ray diffraction analysis.
• Biophysical Analysis: Employed in techniques such as surface plasmon resonance (SPR), isothermal titration calorimetry (ITC), and nuclear magnetic resonance (NMR) spectroscopy to maintain protein native state.
• Vaccine and Therapeutic Development: Aids in the purification and formulation of membrane protein-based vaccines and biologic drugs.
• Lipid Nanodisc Formation: Used in the creation of lipid nanodiscs to study membrane proteins in a near-native lipid bilayer environment.
• Diagnostic Assay Development: Serves as a stabilizing agent in diagnostic kits and assays that utilize membrane-bound antigens or receptors.

Basic Information

Product Name	Nonyl-β-D-1-Thiomaltoside
CAS No.	148565-55-3
Molecular Formula	C27H50O10S
Molecular Weight	566.75 g/mol
Synonyms	Nonyl β-D-1-Thiomaltoside; n-Nonyl-β-D-thiomaltoside; Nonyl Thiomaltoside; Heptyl β-D-Thiomaltoside (common misnomer); NM; C9-TM; 1-Thio-n-nonyl-β-D-maltoside; 4-O-α-D-Glucopyranosyl-1-thio-β-D-glucopyranoside, nonyl
EINECS	Contact for details

Quality Control

Our Nonyl-β-D-1-Thiomaltoside is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high performance in sensitive applications. Production adheres to cGMP guidelines where applicable. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and critical performance parameters. We support compliance with relevant research and pharmaceutical industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Critical Micelle Concentration (CMC)	0.2 - 0.4 mM (typical in water)
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines
Biological Activity (if applicable)	Maintains protein function in standard assays

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.