Description

Fmoc-N(Hmb)-Gly-Oh CAS NO 148515-78-0 is a specialized, orthogonally protected amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound matters because it provides critical control over side-chain reactivity, enabling the synthesis of complex peptides with high fidelity and reduced side reactions. It is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and academic research who require precise building blocks for novel peptide therapeutics and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled, sequential assembly of peptides, particularly those containing sensitive residues.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs) for peptide-based drugs.
• Bioconjugation: Serves as a linker or modified amino acid for creating peptide-protein or peptide-small molecule conjugates.
• Chemical Biology Research: Employed in the synthesis of peptide probes, inhibitors, and tools for studying biological mechanisms.
• Combinatorial Chemistry: Utilized in libraries for high-throughput screening to discover new bioactive compounds.
• Glycopeptide Synthesis: The Hmb (2-hydroxy-4-methoxybenzyl) protection allows for the synthesis of peptides where standard side-chain protection strategies are incompatible.

Basic Information

Product Name	Fmoc-N(Hmb)-Gly-Oh
CAS No.	148515-78-0
Molecular Formula	C26H25NO6
Molecular Weight	447.48 g/mol
Synonyms	Fmoc-N-(2-Hydroxy-4-methoxybenzyl)glycine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-(2-hydroxy-4-methoxybenzyl)glycine; Fmoc-Hmb-Gly-OH; Nα-Fmoc-Nβ-(2-hydroxy-4-methoxybenzyl)glycine; Fmoc-N(2-Hydroxy-4-methoxybenzyl)glycine; Fmoc-N-(Hmb)-Gly-OH; N-Fmoc-N-(2-hydroxy-4-methoxybenzyl)glycine
EINECS	Contact for details

Quality Control

Our Fmoc-N(Hmb)-Gly-Oh is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and light-sensitive (store away from light); therefore, containers must be kept sealed under inert atmosphere (e.g., argon or nitrogen) when not in use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.