Description

1,2-Dipalmitoyl-Sn-Glycero-3-Phospho(Ethylene Glycol) (Sodium Salt) is a high-purity, synthetic phospholipid derivative, specifically a polyethylene glycol (PEG)-ylated phosphatidylethanolamine. This compound is a critical functional excipient and building block in advanced pharmaceutical and biotechnological formulations. It is primarily used by researchers and manufacturers in the life sciences sector to enhance the stability, circulation time, and targeting efficiency of lipid-based delivery systems. Its unique amphiphilic structure makes it indispensable for creating stealth liposomes and other nanocarriers.

Application

• Liposome and Nanoparticle Formulation: As a key component for creating long-circulating "stealth" liposomes and lipid nanoparticles (LNPs) for drug and gene delivery.
• mRNA Vaccine & Therapeutic Delivery: A critical PEG-lipid conjugate used in the lipid bilayer of mRNA-LNPs to modulate pharmacokinetics and reduce immunogenic clearance.
• Targeted Drug Delivery Systems: Serves as an anchor point for attaching targeting ligands (e.g., antibodies, peptides) to liposomal surfaces for site-specific therapy.
• Diagnostic Agent Carrier: Used in the formulation of contrast agents for medical imaging (e.g., MRI, ultrasound) to improve stability and biodistribution.
• Biomimetic Membrane Research: A tool for studying membrane fluidity, protein-lipid interactions, and the behavior of PEGylated surfaces in model membranes.
• Cosmetic & Dermal Delivery: Incorporated into nanocarriers for the topical delivery of active ingredients, enhancing skin penetration and retention.

Basic Information

Product Name	1,2-Dipalmitoyl-Sn-Glycero-3-Phospho(Ethylene Glycol) (Sodium Salt)
CAS No.	148439-06-9
Molecular Formula	C39H76NaO10P
Molecular Weight	758.98 g/mol
Synonyms	DPPE-PEG (Sodium Salt); 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)] (Sodium Salt); PEGylated DPPE; PEG-DPPE; 16:0 PEG PE; mPEG-DPPE; Poly(ethylene glycol) derivatized phosphatidylethanolamine; DSPE-PEG (when referring to distearoyl, a common related compound)
EINECS	Contact for details

Quality Control

Our 1,2-Dipalmitoyl-Sn-Glycero-3-Phospho(Ethylene Glycol) (Sodium Salt) is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity and assay, NMR for structural confirmation, and mass spectrometry. We provide comprehensive Certificates of Analysis (COA) detailing all specifications. Production can be aligned with cGMP guidelines for pharmaceutical applications, ensuring traceability and consistency for critical drug delivery projects.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). For long-term storage, keep under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (NMR)	Complies with structure
Identification (Mass Spec)	Complies
Purity (HPLC)	≥ 95.0%
Assay (Phosphorus Content)	95.0 - 105.0% of theoretical
Water Content (KF)	≤ 3.0%
Residual Solvents (GC)	Meets ICH guidelines
Bacterial Endotoxins	< 10 EU/mg (if required)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.