Description

[O6-(Dimethoxytrityl)Hexyl][6'-Hydroxyhexyl]Disulfide CAS NO 148254-18-6 is a specialized bifunctional disulfide linker compound, featuring both a dimethoxytrityl (DMT) protecting group and a terminal hydroxyl group. This unique molecular architecture makes it a critical intermediate for the controlled synthesis and functionalization of oligonucleotides and other biomolecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced drug discovery, particularly for the development of antisense oligonucleotides, siRNA, and other therapeutic nucleic acid modalities. The compound enables precise conjugation and labeling strategies essential for modern bioconjugation and targeted delivery systems.

Application

• Oligonucleotide Synthesis: As a key bifunctional linker for introducing disulfide bonds into oligonucleotide sequences, enabling reversible conjugation and controlled release mechanisms.
• Bioconjugation & Labeling: For attaching reporter molecules (e.g., fluorophores, peptides) to biomolecules via the hydroxyl group, with the DMT group allowing for selective deprotection and further modification.
• Therapeutic Nucleic Acid Development: Critical in the research and production of antisense oligonucleotides, siRNA, and aptamers where site-specific modification is required for stability and targeting.
• Solid-Phase Synthesis: Used as a building block in automated solid-phase synthesizers for the stepwise construction of complex, functionalized molecular architectures.
• Prodrug & Delivery System Design: Facilitates the creation of cleavable linkers in prodrugs and nanoparticle-based delivery systems, leveraging the reducible disulfide bond for triggered activation in specific cellular environments.
• Cross-linking Agent: Employed in biochemical research to create reversible cross-links between molecules, useful for studying protein-nucleic acid interactions or constructing molecular assemblies.

Basic Information

Product Name	[O6-(Dimethoxytrityl)Hexyl][6'-Hydroxyhexyl]Disulfide
CAS No.	148254-18-6
Molecular Formula	C39H48O4S2
Molecular Weight	644.92 g/mol
Synonyms	6-({6-[(4,4'-Dimethoxytrityl)oxy]hexyl}disulfanyl)hexan-1-ol; DMT-Hexyl-SS-Hexanol; 1,6-Hexanediol, 6-[[6-[(4,4'-dimethoxytrityl)oxy]hexyl]dithio]-, (6R)-; O6-(4,4'-Dimethoxytrityl)hexyl 6'-hydroxyhexyl disulfide; DMT-Hexyl Disulfide Hexanol; Bifunctional DMT-disulfide linker; Hydroxyhexyl DMT-hexyl disulfide
EINECS	Contact for details

Quality Control

Our [O6-(Dimethoxytrityl)Hexyl][6'-Hydroxyhexyl]Disulfide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive oligonucleotide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and mass spectrometry. We support cGMP compliance for advanced therapeutic medicinal product (ATMP) development and can provide documentation to meet the stringent requirements of pharmaceutical and biotech research.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider storing under an inert atmosphere (argon or nitrogen) to prevent oxidation of the disulfide bond and degradation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.