Description

2-(4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)phenyl)acetic acid is a specialized photoaffinity labeling reagent featuring a reactive diazirine group and a carboxylic acid handle. This compound is critical for researchers developing covalent probes to study protein-ligand interactions, protein-protein interactions, and biological target identification. It is primarily utilized by pharmaceutical R&D teams, chemical biologists, and academic research groups in the life sciences sector for advanced proteomics and drug discovery applications.

Application

• Photoaffinity Labeling (PAL): A key reagent for synthesizing photoactivatable probes to capture transient or weak biomolecular interactions.
• Chemical Proteomics: Used in activity-based protein profiling (ABPP) to identify and validate novel drug targets.
• Bioconjugation: The carboxylic acid moiety allows for covalent attachment to amines, enabling the synthesis of labeled peptides, proteins, or small molecules.
• Drug Discovery: Integral to creating covalent inhibitors and understanding binding sites for structure-based drug design.
• Material Science: Potential use in surface functionalization and creating photo-crosslinkable polymers.

Basic Information

Product Name	2-(4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)phenyl)acetic acid
CAS No.	148058-40-6
Molecular Formula	C11H7F3N2O2
Molecular Weight	256.18 g/mol
Synonyms	3-[4-(Carboxymethyl)phenyl]-3-(trifluoromethyl)-3H-diazirine; 4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)benzenacetic acid; 2-[4-[3-(Trifluoromethyl)diazirin-3-yl]phenyl]acetic acid; TPD-Acetic Acid; Photoaffinity Labeling Reagent 148058-40-6; Trifluoromethylphenyl Diazirine Acetic Acid; TFDZ-AA
EINECS	Contact for details

Quality Control

Our production of 2-(4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)phenyl)acetic acid adheres to stringent quality protocols suitable for research and development applications. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and MS to confirm structural identity and purity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to ensure traceability and reproducibility for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.