Description

m-Peg4-Succinimidyl Carbonate is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring an amine-reactive N-hydroxysuccinimide (NHS) ester and a methoxy terminus. This compound is essential for creating stable, hydrophilic spacers in bioconjugation, significantly improving the solubility and pharmacokinetic profiles of therapeutic molecules. It is a critical reagent for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing advanced drug delivery systems, antibody-drug conjugates (ADCs), and diagnostic probes.

Application

• Bioconjugation and PEGylation: Primary reagent for covalently attaching PEG chains to proteins, peptides, antibodies, and other amine-containing biomolecules to enhance solubility, reduce immunogenicity, and prolong circulation half-life.
• Antibody-Drug Conjugate (ADC) Development: Used as a linker to connect cytotoxic payloads to monoclonal antibodies, creating stable and effective targeted cancer therapies.
• Drug Delivery System Fabrication: Functionalizes nanoparticles, liposomes, and polymeric micelles to improve targeting, stability, and controlled release of encapsulated drugs.
• Diagnostic Reagent Synthesis: Conjugates dyes, fluorophores, or other detection moieties to antibodies and proteins for use in immunoassays, flow cytometry, and in vivo imaging.
• Surface Modification: Used to create non-fouling, biocompatible coatings on medical devices, biosensors, and implantable materials by grafting PEG layers onto amine-functionalized surfaces.
• Crosslinking Agent: Serves as a homobifunctional crosslinker between amine groups in hydrogel formation and biomaterial engineering.

Basic Information

Product Name	m-Peg4-Succinimidyl Carbonate
CAS No.	147912-03-6
Molecular Formula	C17H29NO10
Molecular Weight	407.41 g/mol
Synonyms	mPEG4-SC; mPEG4-NHS Ester; Methoxy-PEG4-NHS ester; α-Methoxy-ω-succinimidyl carbonate PEG4; 2,5-Dioxopyrrolidin-1-yl 2,5,8,11-tetraoxatetradecan-14-oate; 17-Methoxy-4,7,10,13-tetraoxa-16-azanonadecan-19-oic acid 2,5-dioxopyrrolidin-1-yl ester; NHS-PEG4-OMe; SC-PEG4-OMe
EINECS	Contact for details

Quality Control

Our m-Peg4-Succinimidyl Carbonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to guarantee traceability, consistency, and reliability for your research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, and dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.