Description

1,2-Bis(12-Methoxydodecanoyl)-Sn-Glycero-3-Phosphocholine is a synthetic, structured phospholipid derivative, specifically a phosphatidylcholine analog with defined methoxy-terminated acyl chains. This compound is valued for its role as a key building block in advanced lipid-based delivery systems, offering precise control over physicochemical properties. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for developing novel liposomal formulations, lipid nanoparticles (LNPs), and other sophisticated drug delivery platforms.

Application

• Drug Delivery Systems: A critical component in the formulation of liposomes and lipid nanoparticles (LNPs) for targeted and sustained release of active pharmaceutical ingredients (APIs).
• mRNA Vaccine & Therapeutic Formulations: Used as a functional, ionizable, or helper lipid to enhance the stability, encapsulation efficiency, and cellular delivery of nucleic acids.
• Biomembrane Research: Serves as a model phospholipid for studying membrane fluidity, phase behavior, and protein-lipid interactions due to its tailored acyl chain structure.
• Cosmetic & Dermal Delivery: Incorporated into nanocarriers for the topical delivery of vitamins, antioxidants, and other active cosmetic ingredients.
• Diagnostic Agent Carriers: Employed in the development of contrast agents and imaging probes for diagnostic applications.
• Gene Therapy Vectors: Aids in the construction of non-viral vectors for the safe and efficient transfection of genetic material.

Basic Information

Product Name	1,2-Bis(12-Methoxydodecanoyl)-Sn-Glycero-3-Phosphocholine
CAS No.	147810-10-4
Molecular Formula	C38H76NO10P
Molecular Weight	737.99 g/mol
Synonyms	1,2-Di-O-(12-Methoxydodecanoyl)-sn-glycero-3-phosphocholine; PC(12:0(12-OMe)/12:0(12-OMe)); Methoxy-PC; 1,2-Bis(12-methoxylauroyl)-sn-glycero-3-phosphocholine; Defined Chain Phosphatidylcholine; Synthetic Phospholipid 147810-10-4; Lipid for LNPs
EINECS	Contact for details

Quality Control

Our 1,2-Bis(12-Methoxydodecanoyl)-Sn-Glycero-3-Phosphocholine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical and research applications. Comprehensive Certificates of Analysis (COA) detailing purity, residual solvents, and other critical parameters are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.