Description

(-)-Ortho-Cotinine Perchlorate CAS NO 147732-32-9 is a high-purity, stable salt derivative of cotinine, a major metabolite of nicotine. This compound is of significant value as a critical reference standard and analytical reagent in biochemical and pharmacological research. It is primarily needed by research institutions, pharmaceutical development laboratories, and diagnostic manufacturers focusing on nicotine metabolism studies, biomarker quantification, and the development of smoking cessation therapies or diagnostic assays.

Application

• Pharmacological Reference Standard: Used as a certified reference material (CRM) for calibrating analytical instruments in drug metabolism and pharmacokinetics (DMPK) studies.
• Biomarker Analysis: Essential for the accurate quantification of cotinine levels in biological samples (e.g., urine, blood, saliva) for clinical research and exposure assessment.
• Diagnostic Kit Development: Serves as a key component in the formulation and quality control of immunoassays and point-of-care tests designed to detect tobacco use.
• Metabolic Pathway Research: Employed in in vitro and in vivo studies to investigate the detailed pathways of nicotine metabolism and its physiological effects.
• Pharmaceutical Impurity Profiling: Acts as a known impurity standard in the quality control of nicotine-related therapeutic products.
• Forensic Toxicology: Utilized as a calibrant in forensic laboratories for confirming nicotine intake in legal and workplace testing scenarios.

Basic Information

Product Name	(-)-Ortho-Cotinine Perchlorate
CAS No.	147732-32-9
Molecular Formula	C10H12N2O • HClO4
Molecular Weight	284.68 g/mol
Synonyms	(-)-Cotinine Perchlorate; (5S)-1-Methyl-5-(3-pyridyl)-2-pyrrolidinone Perchlorate; L-Cotinine Perchlorate; (S)-Cotinine Perchlorate; Cotinine HClO4; Cotinine Perchlorate Salt; Nicotine Metabolite Perchlorate; 2-Pyrrolidinone, 1-methyl-5-(3-pyridinyl)-, (5S)-, perchlorate
EINECS	Contact for details

Quality Control

Our (-)-Ortho-Cotinine Perchlorate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and residual solvent analysis, to ensure it meets the stringent requirements for research and diagnostic use. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.