Description

5 5'-Dimethyl-Bapta-Am* is a high-purity, specialized calcium chelator and fluorescent calcium indicator precursor. This compound matters for researchers and formulators requiring precise control and measurement of intracellular calcium ion (Ca²⁺) concentrations in biological systems. It is primarily needed by the life sciences research sector, pharmaceutical development, and diagnostic reagent manufacturing for applications in cell biology, neuroscience, and high-throughput screening.

Application

• Fluorescent Calcium Indicator Synthesis: A key intermediate in the preparation of advanced, cell-permeable calcium-sensitive dyes like dimethyl-BAPTA derivatives.
• Intracellular Calcium Chelation: Used in biochemical research to buffer and control free calcium levels within cells, enabling the study of calcium-dependent signaling pathways.
• Neuroscience & Physiology Research: Essential for investigating calcium flux in neurons, muscle cells, and other excitable tissues.
• Drug Discovery Assays: Employed in the development of high-throughput screening (HTS) assays to identify compounds that modulate calcium channels or calcium-mediated processes.
• Diagnostic Reagent Formulation: A component in the formulation of specialized kits and reagents for clinical and research diagnostics related to cellular function.
• Biochemical Tool Development: Serves as a foundational chemical tool for creating custom probes to study metal ion homeostasis and signaling.

Basic Information

Product Name	5 5'-Dimethyl-Bapta-Am*
CAS No.	147504-94-7
Molecular Formula	C24H28N2O10
Molecular Weight	504.49 g/mol
Synonyms	1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid, 5,5'-Dimethyl derivative; 5,5'-Dimethyl-BAPTA-AM; 5,5'-Dimethyl BAPTA acetoxymethyl ester; DM-BAPTA-AM; BAPTA-AM, 5,5'-dimethyl-; Calcium indicator precursor DM-BAPTA-AM; Glycine, N,N'-[1,2-ethanediylbis[oxy(5-methyl-2,1-phenylene)]]bis[N-(carboxymethyl)-, tetrakis(acetoxymethyl) ester]; Tetrakis(acetoxymethyl) 5,5'-dimethyl-BAPTA ester
EINECS	Contact for details

Quality Control

Our 5 5'-Dimethyl-Bapta-Am* is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with research-grade standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term stability, store in a freezer and allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.