Description

Cmp Sialic Acid, [Sialic-6-14C] CAS NO 147385-62-4 is a carbon-14 radiolabeled derivative of sialic acid, a critical monosaccharide involved in numerous biological recognition processes. This isotopically labeled compound is essential for conducting precise metabolic and pharmacokinetic tracer studies, enabling researchers to track the incorporation and fate of sialic acid in complex biological systems. It is primarily utilized by pharmaceutical R&D teams, academic biochemists, and contract research organizations (CROs) focused on glycobiology, biomarker discovery, and the development of novel therapeutics.

Application

• Metabolic Pathway Tracing: Used as a radiotracer to study the biosynthesis, turnover, and catabolic pathways of sialic acid in cell cultures and animal models.
• Glycoconjugate Research: Investigates the incorporation of sialic acid into glycoproteins, glycolipids, and polysaccharides, crucial for understanding cell surface signaling and immune response.
• Drug Metabolism and Pharmacokinetics (DMPK): Facilitates ADME (Absorption, Distribution, Metabolism, Excretion) studies for drug candidates targeting sialic acid-related pathways.
• Enzyme Activity Assays: Serves as a substrate for sialyltransferases, sialidases, and other enzymes involved in glycan modification, allowing for precise kinetic measurements.
• Diagnostic Probe Development: Aids in the creation of imaging probes or diagnostic assays for diseases where sialic acid expression is altered, such as cancer and inflammation.
• Quality Control Reference: Acts as an internal standard in analytical methods like LC-MS for the quantification of sialic acid in biological samples.

Basic Information

Product Name	Cmp Sialic Acid, [Sialic-6-14C]
CAS No.	147385-62-4
Molecular Formula	C11H19NO9 * (14C labeled)
Molecular Weight	Contact for details
Synonyms	N-Acetylneuraminic-6-14C Acid; 5-Acetamido-3,5-dideoxy-D-glycero-D-galacto-non-2-ulopyranosonic-6-14C Acid; Sia-6-14C; Neu5Ac-6-14C; [6-14C]-Sialic Acid; Radiolabeled Sialic Acid; Carbon-14 Labeled NANA
EINECS	Contact for details

Quality Control

Every batch of Cmp Sialic Acid, [Sialic-6-14C] is manufactured and analyzed under strict quality systems to ensure identity, purity, and specific activity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request and provide detailed data on radiochemical purity, specific activity, chemical purity (HPLC), and solvent content.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to keep the material desiccated. Handle and dispose of in accordance with all applicable radiation safety regulations and guidelines.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95% (Chemical Purity)
Radiochemical Purity (Radio-HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent (Residual)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.