Description

Nolatrexed CAS NO 147149-76-6 is a synthetic thymidylate synthase inhibitor belonging to the quinazoline class of compounds. This compound is of significant interest in pharmaceutical research and development due to its targeted mechanism of action. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel anticancer therapeutics.

Application

• Anticancer Research: A key investigational agent for studying thymidylate synthase inhibition in various cancer cell lines and preclinical models.
• Biochemical Assay Development: Used as a reference standard or active compound in high-throughput screening (HTS) assays to identify new drug candidates.
• Mechanism of Action Studies: Employed in pharmacological research to understand folate metabolism pathways and resistance mechanisms in oncology.
• Pharmaceutical Intermediate: Serves as a critical building block or precursor in the synthesis of more complex therapeutic agents.
• Reference Standard: Provides a certified material for analytical method development, validation, and quality control in laboratory settings.

Basic Information

Item	Detail
Product Name	Nolatrexed
CAS No.	147149-76-6
Molecular Formula	C19H20N4O3
Molecular Weight	352.39 g/mol
Synonyms	AG337; Thymitaq; 2-Desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid; 5-Methyl-5,8-dideaza-2-desamino-N10-propargylfolic acid; Nolatrexed dihydrochloride (salt form); CB 3004; NSC 672070; Quinazoline antifolate
EINECS	Contact for details

Quality Control

Our Nolatrexed is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.