Description

Ezlopitant CAS NO 147116-64-1 is a potent and selective non-peptide neurokinin 1 (NK1) receptor antagonist. This compound is of significant interest in pharmaceutical research and development for its potential to modulate neurokinin-mediated pathways. It is primarily utilized by researchers and manufacturers in the life sciences sector for preclinical studies and as a key intermediate in the synthesis of novel therapeutic agents targeting conditions such as nausea, vomiting, and central nervous system disorders.

Application

• Pharmaceutical Research: Serves as a critical reference standard and pharmacological tool in neurokinin receptor studies.
• Drug Discovery: Used as a lead compound or intermediate in the development of new antiemetic and anxiolytic medications.
• Preclinical Development: Employed in animal model studies to investigate the efficacy and mechanism of action of NK1 antagonists.
• Biochemical Assays: Acts as a selective inhibitor in receptor binding and functional assays to characterize NK1 receptor activity.
• Academic Research: Utilized in university and institutional labs for fundamental research on the role of substance P and neurokinin signaling.
• GMP Intermediate: Potential use as a starting material or intermediate in the cGMP-compliant synthesis of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Ezlopitant
CAS No.	147116-64-1
Molecular Formula	C₂₃H₂₄N₂O₃
Molecular Weight	376.45 g/mol
Synonyms	CJ-11,974; CJ 11,974; (2S,3S)-3-((3,5-Bis(trifluoromethyl)benzyl)oxy)-2-phenylpiperidine; 3-[[[3,5-Bis(trifluoromethyl)phenyl]methoxy]-(2S)-2-phenyl-3-piperidinol; (3S)-3-({[3,5-Bis(trifluoromethyl)phenyl]methoxy})-2-phenylpiperidine
EINECS	Contact for details

Quality Control

Our Ezlopitant is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and mass spectrometry. We adhere to relevant industry guidelines to support our customers' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect the light-sensitive material from degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.