Description

Fos-Choline-15, Sol-Grade is a high-purity, synthetic phospholipid analog specifically designed for solubilization applications. This compound is critical for creating stable, clear solutions of membrane proteins and other challenging biomolecules in biochemical and biophysical research. It is an essential reagent for structural biologists, enzymologists, and pharmaceutical researchers working on drug discovery and target characterization. The Sol-Grade designation ensures optimal performance in demanding experimental protocols.

Application

• Membrane Protein Solubilization: Primary use for extracting and stabilizing integral membrane proteins from cellular membranes for functional and structural studies.
• Biophysical Analysis: Preparation of samples for techniques such as X-ray crystallography, cryo-electron microscopy (cryo-EM), and nuclear magnetic resonance (NMR) spectroscopy.
• Lipid Nanodisc Formation: Used in the creation of nanoscale lipid bilayers (nanodiscs) to study membrane proteins in a near-native lipid environment.
• Drug Discovery Screening: Enables the reconstitution of membrane-bound drug targets for high-throughput screening (HTS) assays.
• Enzyme Activity Studies: Provides a suitable detergent environment to study the kinetics and mechanisms of lipid-dependent enzymes.
• Vesicle and Liposome Preparation: Acts as a key component in the formulation of model membranes for delivery and fusion studies.

Basic Information

Product Name	Fos-Choline-15, Sol-Grade
CAS No.	146801-07-2
Molecular Formula	C22H48NO4P
Molecular Weight	421.60 g/mol
Synonyms	FOS-Choline-15; Foscholine-15; 1-Tetradecanoyl-2-hydroxy-sn-glycero-3-phosphocholine; Lyso myristoyl phosphatidylcholine; LMPC; 1-Myristoyl-2-hydroxy-sn-glycero-3-phosphocholine; 1-Myristoyl-lyso-phosphatidylcholine; 1-Myristoyl-2-lyso-sn-glycero-3-phosphocholine; n-Tetradecanoyl lysophosphatidylcholine
EINECS	Contact for details

Quality Control

Our Fos-Choline-15, Sol-Grade is manufactured under strict quality systems to ensure batch-to-batch consistency and high performance in sensitive research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and critical functional parameters. We adhere to relevant guidelines for research-grade biochemicals to guarantee reliability for your most demanding experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. Under these conditions, the product is stable for at least two years from the date of receipt. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Critical Micelle Concentration (CMC)	Typically 0.1 - 0.3 mM
Solubility	Soluble in water, chloroform, methanol
Heavy Metals	< 10 ppm
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.