Description

Arachidonoyl Thio-Pc CAS NO 146797-82-2 is a specialized phospholipid analog, a thioester derivative of arachidonic acid and phosphatidylcholine. This compound is a critical biochemical tool and synthetic intermediate for studying lipid metabolism, signal transduction, and membrane dynamics. It is primarily utilized by research institutions and pharmaceutical developers focused on lipidomics, inflammation pathways, and novel drug delivery systems.

Application

• Biochemical Research: A key substrate and inhibitor for studying phospholipase A2 (PLA2) and other lipase enzymes involved in arachidonic acid release.
• Lipidomics & Metabolomics: Used as a standard or internal standard in mass spectrometry-based analysis of complex lipid profiles and metabolic pathways.
• Drug Discovery: Serves as a synthetic intermediate or a model compound for developing novel anti-inflammatory agents and modulators of eicosanoid signaling.
• Membrane Biophysics: Employed in the fabrication of model lipid bilayers and liposomes to investigate membrane fluidity, protein-lipid interactions, and permeability.
• Cell Signaling Studies: Utilized to probe the role of specific phospholipid pools in intracellular signaling cascades related to inflammation and cellular stress responses.
• Pharmaceutical Formulation: Investigated as a component in advanced liposomal or nanoparticle-based delivery systems for targeted therapeutics.

Basic Information

Product Name	Arachidonoyl Thio-Pc
CAS No.	146797-82-2
Molecular Formula	C46H80NO7PS
Molecular Weight	822.16 g/mol
Synonyms	1-Arachidonoyl-2-hydroxy-sn-glycero-3-phosphocholine thioester; Arachidonoyl thiophosphatidylcholine; 1-Arachidonoyl-2-lyso-sn-glycero-3-phosphocholine thioester; Thio-PAF analog (arachidonoyl); Arachidonic acid thioester of lyso-PC; PLA2 substrate analog; sn-Glycero-3-phosphocholine, 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hydroxy-, thioester; Lipid thioester research chemical
EINECS	Contact for details

Quality Control

Every batch of Arachidonoyl Thio-Pc is produced and analyzed under strict quality protocols to ensure identity, purity, and stability for sensitive research applications. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry for comprehensive characterization. A detailed Certificate of Analysis (COA) documenting purity, assay, and impurity profiles is provided with each shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Store away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay	≥ 90% (by weight)
Solubility	Soluble in chloroform, DMSO, ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.