Description

trans-3'-Benzoyloxy Cotinine 2,3,4-Tri-o-Acetyl-n-β-D-Glucuronide Methyl Ester Bromide is a high-purity, advanced chemical intermediate designed for specialized research and development. This compound is critical for analytical chemistry, serving as a key reference standard and metabolite derivative in pharmacokinetic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on nicotine metabolism and biomarker analysis.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the quantification and validation of nicotine metabolites in bioanalytical methods.
• Metabolite Synthesis: Serves as a crucial intermediate in the chemical synthesis of complex cotinine glucuronide derivatives for research.
• Biomarker Research: Essential for developing and calibrating assays in clinical and forensic toxicology studies related to tobacco use.
• Drug Metabolism & Pharmacokinetics (DMPK): Employed in in vitro and in vivo studies to understand the glucuronidation pathway of cotinine.
• Analytical Method Development: A key component for optimizing HPLC, LC-MS, and GC-MS methodologies in analytical laboratories.

Basic Information

Product Name	trans-3'-Benzoyloxy Cotinine 2,3,4-Tri-o-Acetyl-n-β-D-Glucuronide Methyl Ester Bromide
CAS No.	146490-58-6
Molecular Formula	C32H34BrNO13
Molecular Weight	720.52 g/mol
Synonyms	trans-3'-Hydroxycotinine O-β-D-Glucuronide Methyl Ester 2,3,4-Triacetate Benzoate Bromide; Cotinine N-Glucuronide Triacetate Methyl Ester Benzoate Derivative; (5S)-1-Methyl-5-(3-pyridyl)-2-pyrrolidinone 3'-O-(β-D-Glucopyranosiduronic acid) Methyl Ester 2,3,4-Triacetate Benzoate Salt; trans-3'-Benzoyloxycotinine β-D-Glucuronide Triacetate Methyl Ester Bromide; Nicotine Metabolite Derivative; 146490-58-6; Cotinine Glucuronide Ester Bromide
EINECS	Contact for details

Quality Control

Our trans-3'-Benzoyloxy Cotinine 2,3,4-Tri-o-Acetyl-n-β-D-Glucuronide Methyl Ester Bromide is manufactured under controlled conditions to ensure the highest standards of purity and consistency. Each batch undergoes rigorous analytical testing, including HPLC for assay and purity, and is supported by a comprehensive Certificate of Analysis (COA). We adhere to strict quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.