Description

10-Propargyl-10-Deazaaminopterin is a synthetic analog of aminopterin, designed as a potent inhibitor of dihydrofolate reductase (DHFR). This compound matters for researchers and developers in the pharmaceutical sector due to its targeted mechanism of action and potential for enhanced therapeutic profiles. It is primarily needed by organizations engaged in anticancer drug discovery, biochemical research, and the development of novel chemotherapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel antifolate chemotherapeutic agents.
• Biochemical Research: Used as a potent and selective inhibitor of dihydrofolate reductase (DHFR) in enzymatic and cellular pathway studies.
• Oncology R&D: Investigated for its potential antitumor activity and mechanism in various cancer cell line models.
• Structure-Activity Relationship (SAR) Studies: Employed to understand the impact of structural modifications on folate antagonist potency and selectivity.
• Reference Standard: Utilized as an analytical standard in quality control and method development for pharmaceutical analysis.

Basic Information

Product Name	10-Propargyl-10-Deazaaminopterin
CAS No.	146464-95-1
Molecular Formula	C₂₁H₂₂N₈O₄
Molecular Weight	450.45 g/mol
Synonyms	10-Propargyl-10-deazaaminopterin; 10-Propargyl-10-DAM; PDX (Propargyl-Deazaaminopterin); 4-Amino-10-propargyl-10-deazapteroic acid; NSC 706995; AG 2037; 10-Propargyl-10-deazafolic acid analog; Antifolate DHFR inhibitor 10-propargyl
EINECS	Contact for details

Quality Control

Our 10-Propargyl-10-Deazaaminopterin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. Keep the container in a dry, cool, and well-ventilated area. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.