Description

Bastadin 14 CAS NO 146345-73-5 is a brominated tyrosine-derived alkaloid, a member of the bastadin family of marine natural products. This compound is of significant interest in biochemical and pharmacological research due to its potent and selective activity as an inhibitor of the IP3 receptor, a key regulator of intracellular calcium signaling. It serves as a critical research tool for scientists in the fields of cell biology, neurobiology, and drug discovery, enabling the study of calcium-dependent cellular processes and the development of novel therapeutic targets.

Application

• Biochemical Research: Used as a selective and potent inhibitor of the inositol 1,4,5-trisphosphate (IP3) receptor to study intracellular calcium (Ca²⁺) release and signaling pathways.
• Pharmacological Studies: A valuable tool compound for investigating the role of IP3 receptors in various disease models, including neurological disorders, cardiac function, and cancer cell proliferation.
• Cell Biology: Employed to dissect calcium-mediated cellular events such as muscle contraction, neurotransmitter release, gene transcription, and apoptosis.
• Drug Discovery: Serves as a reference standard and a lead structure for the development of novel therapeutics targeting calcium signaling dysregulation.
• Marine Natural Product Research: Studied for its unique brominated bis-oxime structure and its ecological role as a defensive metabolite from marine sponges.

Basic Information

Product Name	Bastadin 14
CAS No.	146345-73-5
Molecular Formula	C34H32Br4N4O8
Molecular Weight	936.16 g/mol
Synonyms	Bastadin-14; 5,5'-[1,2-Ethanediylbis(nitrilo-1-oxo-2,1-ethanediyloxy)]bis[3-bromo-4-(2,4-dibromophenoxy)benzoic acid]; 5,5'-[Ethane-1,2-diylbis(nitrilomethanylylidene)]bis(oxy)bis[3-bromo-4-(2,4-dibromophenoxy)benzoic acid]; IP3 Receptor Inhibitor Bastadin 14
EINECS	Contact for details

Quality Control

Our Bastadin 14 is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity determination and spectroscopic methods (NMR, MS) for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the identity, purity, and analytical data.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, desiccate to protect from moisture. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.