Description

1,10-Di-o-(2-Acetamido-2-Deoxyglucopyranosyl)-2-Azi-1,10-Decanediol is a specialized synthetic compound featuring a unique bifunctional structure that combines a diazirine photoaffinity label with a carbohydrate-derived linker. This molecular architecture makes it a valuable tool for advanced biochemical research, particularly in the study of protein-ligand interactions and biomolecular crosslinking. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in proteomics, drug discovery, and the development of diagnostic assays.

Application

• Photoaffinity Labeling (PAL): Acts as a critical reagent for covalently capturing transient or weak interactions between proteins and small molecules or other biomolecules upon UV light activation.
• Chemical Biology Probes: Used to synthesize probes for target identification and validation in drug discovery pipelines.
• Proteomics Research: Facilitates the mapping of binding sites and interaction networks within complex biological systems.
• Glycobiology Studies: Serves as a functionalized building block for investigating carbohydrate-protein interactions due to its glucosamine-derived structure.
• Bioconjugation & Crosslinking: Enables the site-specific crosslinking of biomolecules for creating stable complexes for analysis or therapeutic applications.
• Material Science Functionalization: Can be used to introduce photoreactive and biologically active groups onto surfaces or polymers for biosensor development.

Basic Information

Product Name	1,10-Di-o-(2-Acetamido-2-Deoxyglucopyranosyl)-2-Azi-1,10-Decanediol
CAS No.	146294-05-5
Molecular Formula	C30H52N4O14
Molecular Weight	668.76 g/mol
Synonyms	1,10-Bis-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-2-diaziridin-1-yl-1,10-decanediol; 2-Azi-1,10-decanediol, 1,10-bis-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl) derivative; Diazirine-labeled bis-glucosamine linker; Photoaffinity crosslinker with carbohydrate spacer; Bifunctional diazirine reagent; N,N'-Diacetylchitobiosyl diazirine crosslinker
EINECS	Contact for details

Quality Control

Our 1,10-Di-o-(2-Acetamido-2-Deoxyglucopyranosyl)-2-Azi-1,10-Decanediol is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. Allow the container to reach room temperature in a desiccator before opening to minimize moisture uptake. For long-term stability, store desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.