Description

Propargyl-Peg2-Tos is a high-purity, functionalized polyethylene glycol derivative featuring a propargyl group and a tosylate leaving group, designed for advanced bioconjugation and chemical synthesis. This compound is a critical building block for creating stable, site-specific linkages in the development of pharmaceuticals, diagnostics, and novel materials. It is primarily utilized by researchers and process chemists in the pharmaceutical, biotechnology, and advanced materials sectors for click chemistry applications, polymer modification, and the synthesis of antibody-drug conjugates (ADCs).

Application

• Click Chemistry Reagent: Serves as a key intermediate for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions to create triazole linkages.
• Bioconjugation & ADC Development: Enables the site-specific attachment of payloads (e.g., toxins, dyes, drugs) to proteins, antibodies, or peptides via its reactive tosylate and propargyl groups.
• Polymer & Material Science: Used to functionalize polymer backbones or nanoparticle surfaces with alkyne handles for further modular assembly.
• Proteomics Research: Acts as a chemical probe or linker for labeling and studying biomolecular interactions.
• Diagnostic Reagent Synthesis: Employed in the production of contrast agents, fluorescent probes, and other diagnostic tools.
• Pharmaceutical Intermediate: A versatile synthon in the multi-step synthesis of complex active pharmaceutical ingredients (APIs) and prodrugs.

Basic Information

Item	Detail
Product Name	Propargyl-Peg2-Tos
CAS No.	145916-41-2
Molecular Formula	C₁₈H₂₆O₇S
Molecular Weight	386.46 g/mol
Synonyms	Propargyl-PEG2-tosylate; 2-[2-(2-Prop-2-ynoxyethoxy)ethoxy]ethyl 4-methylbenzenesulfonate; Tos-PEG2-Propargyl; Propargyl-PEG2-OTs; PEG2-Propargyl Tosylate; Alkyne-PEG2-OTs; 4-Methylbenzenesulfonic acid 2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]ethyl ester; Propargyloxy-PEG2-tosylate
EINECS	Contact for details

Quality Control

Our Propargyl-Peg2-Tos is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, supporting compliance with research and cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is light-sensitive and should be handled under inert atmosphere when appropriate for prolonged procedures to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.