Description

Thrombin Aptamer CAS NO 145563-68-4 is a synthetic, single-stranded DNA oligonucleotide specifically designed to bind with high affinity and selectivity to the blood coagulation enzyme thrombin. This compound is a critical research tool for studying hemostasis, thrombosis, and anticoagulant mechanisms. It is essential for pharmaceutical R&D, diagnostic assay development, and fundamental biochemical research in the life sciences sector.

Application

• Anticoagulant Research & Development: Serves as a model compound for studying novel anticoagulant and antithrombotic therapies.
• Diagnostic Assay Development: Used as a key component in biosensors and in vitro diagnostic (IVD) kits for thrombin detection.
• Biochemical & Biophysical Studies: Employed in surface plasmon resonance (SPR), isothermal titration calorimetry (ITC), and other techniques to study protein-nucleic acid interactions.
• Aptamer Technology Platform: Acts as a foundational sequence for the development of modified or conjugated aptamers with enhanced stability or targeting properties.
• Academic & Pharmaceutical R&D: A standard reagent in laboratories focused on cardiovascular disease, coagulation pathways, and nucleic acid therapeutics.
• Quality Control & Standardization: Used as a reference standard in the calibration and validation of assays measuring thrombin activity or concentration.

Basic Information

Product Name	Thrombin Aptamer
CAS No.	145563-68-4
Molecular Formula	C154H193N59O96P15
Molecular Weight	~ 4900 g/mol (as sodium salt)
Synonyms	Thrombin-binding Aptamer; TBA; DNA Aptamer against Thrombin; 15-mer Thrombin Aptamer; GGTTGGTGTGGTTGG; HD1; ARC183; Anticoagulant Oligonucleotide; NU172
EINECS	Contact for details

Quality Control

Our Thrombin Aptamer is manufactured under stringent conditions to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and bioactivity. We adhere to ISO 9001 quality management principles, and our production processes are designed to meet the exacting standards required for pharmaceutical and diagnostic research.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive). For long-term stability, store desiccated at -20°C. Aliquot into single-use vials to minimize freeze-thaw cycles and exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (UV)	≥ 85% (by dry weight)
Oligonucleotide Length	15-mer
Sequence (5'→3')	GGTTGGTGTGGTTGG
Endotoxin Level	< 10 EU/mg
Solubility	Soluble in nuclease-free water or TE buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.