Description

o-(11-(5-Cholesten-3-Yloxy)3,6,9-Trioxaundecyl) o-(2-(Galactopyranosyloxy)Ethyl) Phosphorothioate is a sophisticated synthetic compound designed for advanced biochemical and pharmaceutical research. This molecule is engineered to facilitate targeted delivery and cellular uptake, making it a critical tool for developing novel therapeutic and diagnostic agents. It is primarily utilized by researchers and developers in the fields of glycobiology, drug delivery systems, and lipid nanoparticle formulation.

Application

• Lipid Nanoparticle (LNP) Formulation: As a functionalized lipid component for constructing targeted delivery vehicles for mRNA, siRNA, and other nucleic acid therapeutics.
• Cell Membrane Research: Used as a probe or anchor to study membrane dynamics, lipid rafts, and receptor interactions due to its cholesterol and galactose moieties.
• Targeted Drug Delivery: Serves as a ligand in drug conjugates designed for hepatocyte-specific targeting via the asialoglycoprotein receptor (ASGPR).
• Glycoconjugate Synthesis: A key intermediate in the synthesis of complex glycolipids and neoglycoconjugates for immunological studies.
• Diagnostic Agent Development: Incorporated into contrast agents or biosensors for targeted imaging applications.
• Biomimetic Material Science: Used to create functional surfaces or vesicles that mimic natural cell membranes for biosensing and biocompatibility studies.

Basic Information

Product Name	o-(11-(5-Cholesten-3-Yloxy)3,6,9-Trioxaundecyl) o-(2-(Galactopyranosyloxy)Ethyl) Phosphorothioate
CAS No.	145307-64-8
Molecular Formula	C46H81O11PS
Molecular Weight	873.17 g/mol
Synonyms	Galactose-cholesterol phosphorothioate conjugate; Cholesterol-PEG3-Galactose phosphorothioate; 5-Cholesten-3β-yl ω-galactosylpoly(ethylene glycol) phosphorothioate; Galactosyl cholesterol ether phosphorothioate; ASGPR targeting lipid intermediate; Glycolipid mimetic phosphorothioate; Lactosyl cholesterol derivative (phosphorothioate); Chol-PEG3-Gal-S
EINECS	Contact for details

Quality Control

Our o-(11-(5-Cholesten-3-Yloxy)3,6,9-Trioxaundecyl) o-(2-(Galactopyranosyloxy)Ethyl) Phosphorothioate is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support development under cGMP guidelines where required and can provide material for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.