Description

Amino-Peg1-Acid CAS NO 144942-89-2 is a bifunctional polyethylene glycol (PEG) derivative featuring a primary amine group and a carboxylic acid group, separated by a short ethylene glycol spacer. This unique structure makes it an invaluable heterobifunctional crosslinker and spacer arm for bioconjugation and pharmaceutical development. It is essential for researchers and manufacturers in the life sciences sector who require precise, water-soluble linkers to modify peptides, proteins, and other biomolecules. The compound enables the creation of stable, functionalized conjugates with controlled spacing and solubility.

Application

• Bioconjugation Reagent: Used as a heterobifunctional crosslinker to covalently attach amines to carboxyl groups on proteins, antibodies, and peptides.
• Pharmaceutical Linker: Serves as a key building block in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• PEGylation Agent: Functions as a spacer to introduce polyethylene glycol (PEG) chains onto drug molecules or surfaces to enhance solubility, stability, and circulation time.
• Surface Functionalization: Employed to modify nanoparticles, biosensors, and chromatographic media with amine-reactive or carboxyl-reactive groups.
• Polymer Chemistry: Acts as a monomer or chain extender in the synthesis of functionalized, biocompatible polymers and hydrogels.
• Diagnostic Probe Synthesis: Utilized to attach fluorescent dyes, chelators, or other reporter molecules to targeting biomolecules.

Basic Information

Product Name	Amino-Peg1-Acid
CAS No.	144942-89-2
Molecular Formula	C5H11NO3
Molecular Weight	133.15 g/mol
Synonyms	2-[2-(2-Aminoethoxy)ethoxy]acetic acid; 8-Amino-3,6-dioxaoctanoic Acid; Amino-PEG1-acetic acid; Fmoc-8-amino-3,6-dioxaoctanoic acid (protected form); O2O'-Bis(2-aminoethyl)ethylene glycol derivative; H2N-PEG1-COOH; AEAA; AEEA Acid
EINECS	Contact for details

Quality Control

Our Amino-Peg1-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, NMR for structural confirmation, and titration for functional group quantification, to ensure it meets high-purity standards suitable for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.