Description

Demethylxestospongine B is a bioactive marine alkaloid derived from sponge species. This compound is of significant interest for its role as a potent and selective inhibitor of the inositol 1,4,5-trisphosphate (IP3) receptor, a key regulator of intracellular calcium signaling. It serves as a critical research tool for scientists in pharmacology, neuroscience, and cell biology, enabling the study of calcium-mediated cellular processes and disease mechanisms.

Application

• Biochemical Research: Primary tool for studying IP3 receptor function and intracellular calcium (Ca²⁺) signaling pathways.
• Pharmacological Studies: Used to investigate the role of calcium release in various disease models, including neurological disorders and cardiac conditions.
• Cell Biology: Employed in experiments to understand calcium's role in processes like apoptosis, gene expression, and muscle contraction.
• Neuroscience Research: Critical for exploring synaptic plasticity, neurotransmitter release, and neuronal excitability mechanisms.
• Drug Discovery: Serves as a reference compound and a starting point for developing novel therapeutics targeting calcium dysregulation.
• Academic & Institutional R&D: Supplied to universities and research institutes for fundamental scientific investigations.

Basic Information

Product Name	Demethylxestospongine B
CAS No.	144789-03-7
Molecular Formula	C₂₂H₂₈N₂O₄
Molecular Weight	384.47 g/mol
Synonyms	Demethylxestospongin B; Xestospongin B Demethylated; IP3 Receptor Inhibitor; 1H-Isoindol-1-one, 2-[2-(4-hydroxyphenyl)ethyl]-3a,4,9,9a-tetrahydro-4,9a-dimethyl-3-[(2-methyl-1H-indol-3-yl)methyl]-; (3aR,4S,9aS)-2-[2-(4-Hydroxyphenyl)ethyl]-4,9a-dimethyl-3-[(2-methyl-1H-indol-3-yl)methyl]-3a,4,9,9a-tetrahydro-1H-isoindol-1-one
EINECS	Contact for details

Quality Control

Our Demethylxestospongine B is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals to guarantee reliable and reproducible results in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.