Description

Oxythiamine Disulfide Nicotinate is a synthetic derivative of thiamine (vitamin B1) designed for advanced biochemical research and pharmaceutical development. This compound is valued for its role as a potent and specific inhibitor of thiamine-dependent enzymes, making it a critical tool for metabolic pathway studies. It is primarily utilized by research institutions, pharmaceutical R&D departments, and manufacturers of high-purity biochemical reagents.

Application

• Biochemical Research: Used as a specific inhibitor to study thiamine-dependent enzymatic processes, including pyruvate dehydrogenase and transketolase.
• Metabolic Pathway Analysis: Essential for investigating cellular energy metabolism, carbohydrate metabolism, and the pentose phosphate pathway in vitro.
• Pharmaceutical R&D: Serves as a reference standard and an active pharmaceutical ingredient (API) intermediate in the development of novel therapeutic agents.
• Nutritional Science Studies: Employed in research models to induce thiamine deficiency states and study related physiological effects.
• Diagnostic Reagent Manufacturing: A key component in the formulation of specialized diagnostic kits for metabolic disorder testing.
• Academic Research: Used in university and institutional labs for teaching and advanced research in biochemistry and molecular biology.

Basic Information

Product Name	Oxythiamine Disulfide Nicotinate
CAS No.	144722-72-5
Molecular Formula	C19H22N4O3S2
Molecular Weight	418.53 g/mol
Synonyms	Oxythiamine Disulfide Nicotinate; OTDN; Thiamine Disulfide Nicotinate Derivative; 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium Chloride Disulfide with Nicotinic Acid; Vitamin B1 Antagonist Nicotinate; Oxythiamine Pyrophosphate Inhibitor Analog; B1 Inhibitor Disulfide Ester
EINECS	Contact for details

Quality Control

Our Oxythiamine Disulfide Nicotinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for all shipments to ensure compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.