Description

Sulfo-n-Succinimidyl (n-Iodoacetyl)Aminobenzoate is a heterobifunctional crosslinking reagent designed for the conjugation of biomolecules, featuring an amine-reactive NHS ester and a thiol-reactive iodoacetyl group. This compound is critical for creating stable, site-specific linkages in proteins, peptides, and other macromolecules, enabling advanced research and diagnostic assay development. It is primarily utilized by researchers and manufacturers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, and diagnostic kit production.

Application

• Bioconjugation and Protein Labeling: For covalently linking proteins, antibodies, or peptides to enzymes, fluorophores, or other probes.
• Antibody-Drug Conjugate (ADC) Linker Chemistry: Serves as a key reagent in the synthesis of stable linker-payload constructs for targeted cancer therapies.
• Diagnostic Assay Development: Used to immobilize capture antibodies or antigens onto solid surfaces for ELISA and other immunoassays.
• Surface Modification: Functionalization of nanoparticles, beads, or biosensor surfaces with specific biomolecules.
• Affinity Chromatography Ligand Coupling: For attaching thiol-containing ligands to chromatography resins.
• Structural Biology Studies: Crosslinking agent for studying protein-protein interactions and complex structures.

Basic Information

Product Name	Sulfo-n-Succinimidyl (n-Iodoacetyl)Aminobenzoate
CAS No.	144650-93-1
Molecular Formula	C17H16IN2O8S
Molecular Weight	535.29 g/mol
Synonyms	Sulfo-SIAB; SIAB, sulfo-; N-Succinimidyl 4-(Iodoacetamido)benzoate, Sulfonated; 4-((Iodoacetyl)amino)benzoic acid N-hydroxysuccinimide ester sulfonate; 4-Sulfo-N-succinimidyl (iodoacetamido)benzoate; N-Sulfosuccinimidyl (4-iodoacetyl)aminobenzoate; SIA, sulfo-; Heterobifunctional Crosslinker SIAB, sulfo-
EINECS	Contact for details

Quality Control

Our Sulfo-n-Succinimidyl (n-Iodoacetyl)Aminobenzoate is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.