Description

8-Br-Pet-Cgmp Sodium Salt is a chemically modified, cell-permeable analog of cyclic guanosine monophosphate (cGMP), widely used as a potent and selective activator of cGMP-dependent protein kinases (PKG). This compound is critical for researchers investigating intracellular signaling pathways, particularly those related to cardiovascular function, smooth muscle relaxation, and neuronal plasticity. It serves as an essential pharmacological tool for life science research, drug discovery, and biochemical assay development in academic, pharmaceutical, and biotechnology sectors.

Application

• Biochemical Research: As a selective PKG activator to study cGMP-mediated signal transduction pathways in cell-based and in vitro assays.
• Cardiovascular Pharmacology: Investigation of vasodilation, platelet aggregation inhibition, and cardiac contractility mechanisms.
• Neuroscience Studies: Exploration of synaptic plasticity, long-term potentiation (LTP), and neuronal excitability regulated by cGMP-PKG signaling.
• Drug Discovery & Screening: Used as a reference standard and tool compound in high-throughput screening (HTS) campaigns for novel cardiovascular and neurological therapeutics.
• Cellular Physiology: Probing the role of PKG in smooth muscle relaxation, cell proliferation, and apoptosis.
• Diagnostic Development: Potential use in the development of diagnostic kits and assays for monitoring cGMP pathway activity.

Basic Information

Product Name	8-Br-Pet-Cgmp Sodium Salt
CAS No.	144510-04-3
Molecular Formula	C20H22BrN6NaO11P2
Molecular Weight	695.27 g/mol
Synonyms	8-Bromo-PET-cGMP sodium salt; 8-Br-PET-cGMP, Na salt; 8-Bromophenacylthio-cGMP sodium salt; Sodium 8-bromo-2-[(phenacylthio)methyl]-3,5,7-trioxo-1,2,4,6,8-pentaazabicyclo[3.3.0]octane-4-carboxylate; 8-Br-PET-cyclic GMP sodium; 8-Bromo-PET-cGMP; B0784 (APExBIO); SC-203048
EINECS	Contact for details

Quality Control

Our 8-Br-Pet-Cgmp Sodium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable experimental outcomes for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.