Description

8-(2-Aminophenylthio) Guanosine-3',5'-Cyclic Monophosphate Sodium Salt is a chemically modified, cell-permeable analog of cyclic guanosine monophosphate (cGMP). This compound is a crucial research-grade biochemical tool designed to study intracellular signaling pathways, particularly those mediated by cGMP-dependent protein kinases (PKG). It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in cardiovascular, neurological, and metabolic disease research, as well as in high-throughput screening for drug discovery.

Application

• Biochemical Research: Acts as a stable, membrane-permeable activator of cGMP-dependent protein kinases (PKG) for studying signal transduction mechanisms.
• Pharmaceutical Development: Used as a reference standard and a key intermediate in the synthesis of novel therapeutic agents targeting nitric oxide and cGMP pathways.
• Cell Biology Studies: Employed to investigate the role of cGMP in cellular processes such as smooth muscle relaxation, platelet aggregation inhibition, and neuronal plasticity.
• Enzyme Assays: Serves as a specific substrate or activator in enzymatic assays for phosphodiesterases (PDEs) and PKG to evaluate inhibitor efficacy.
• High-Throughput Screening (HTS): A critical component in drug discovery campaigns to identify modulators of the cGMP signaling cascade.

Basic Information

Product Name	8-(2-Aminophenylthio) Guanosine-3',5'-Cyclic Monophosphate Sodium Salt
CAS No.	144509-87-5
Molecular Formula	C16H16N7O7PS1Na1 • xH2O
Molecular Weight	528.36 g/mol (Anhydrous)
Synonyms	8-(2-Aminophenylthio)-cGMP Sodium Salt; 8-ApT-cGMP, Na Salt; 8-(2-Aminophenylthio)guanosine 3',5'-cyclic monophosphate sodium salt; cGMP analog, 8-(2-Aminophenylthio)-; Sodium 8-[(2-aminophenyl)thio]guanosine-3',5'-cyclic monophosphate; PKG Activator; Cell-permeable cGMP analog
EINECS	Contact for details

Quality Control

Our 8-(2-Aminophenylthio) Guanosine-3',5'-Cyclic Monophosphate Sodium Salt is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific tests is provided to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.