Description

6,7-Dihydroxyswainsonine is a polyhydroxylated indolizidine alkaloid, a derivative of the natural product swainsonine. This compound is a highly specific and potent inhibitor of Golgi α-mannosidase II, an enzyme critical for N-linked glycoprotein processing. It serves as a valuable biochemical tool for researchers in glycobiology, cell biology, and immunology, enabling the study of glycosylation pathways and their roles in disease mechanisms such as cancer metastasis and viral infection.

Application

• Glycobiology Research: Used as a selective inhibitor to study N-linked oligosaccharide processing and the biological functions of complex glycans.
• Cancer Research: Investigated for its potential to alter tumor cell surface glycosylation, affecting cell adhesion, signaling, and metastasis.
• Virology Studies: Applied in research on viral entry and pathogenesis, as many viruses utilize host cell glycoproteins for infection.
• Immunology Research: Used to modulate the glycosylation of immune cell receptors and study its impact on immune response and inflammation.
• Biochemical Reagent: Serves as a critical standard and inhibitor in enzymatic assays for α-mannosidase activity.
• Drug Discovery: Acts as a lead compound or pharmacophore for developing novel therapeutics targeting glycosylation enzymes.

Basic Information

Product Name	6,7-Dihydroxyswainsonine
CAS No.	144367-16-8
Molecular Formula	C8H15NO4
Molecular Weight	189.21 g/mol
Synonyms	(1S,2R,8R,8aR)-1,2,8-Trihydroxyoctahydroindolizine; 6,7-Dihydroxyswainsonine; 1,2,8-Trihydroxyindolizidine; Golgi α-mannosidase II inhibitor; Mannosidase inhibitor
EINECS	Contact for details

Quality Control

Our 6,7-Dihydroxyswainsonine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and specific rotation for chiral purity. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.