Description

(1R,2R)-(-)-n-p-Tosyl-1,2-Diphenylethylenediamine CAS NO 144222-34-4 is a high-purity chiral diamine derivative, widely recognized as a versatile and highly effective ligand in asymmetric synthesis. Its core value lies in enabling the production of enantiomerically pure compounds, which is critical for the efficacy and safety of advanced pharmaceuticals and fine chemicals. This product is essential for research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality chiral auxiliaries for catalytic processes.

Application

• Asymmetric Catalysis: Serves as a privileged chiral ligand for transition metal-catalyzed reactions, including hydrogenation, epoxidation, and cyclopropanation.
• Pharmaceutical Intermediate Synthesis: A key building block in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) for drugs targeting central nervous system disorders, cardiovascular diseases, and infections.
• Agrochemical Production: Used in the development of chiral pesticides and herbicides to enhance biological activity and reduce environmental impact.
• Fine Chemical Manufacturing: Employed in the production of specialty chemicals, flavors, and fragrances where stereochemical control is paramount.
• Academic & Process Research: A valuable tool for chemists in method development and exploring new asymmetric transformations in both academic and industrial R&D settings.
• Chiral Resolution Agent: Can be utilized in the separation of racemic mixtures of carboxylic acids and other compounds.

Basic Information

Product Name	(1R,2R)-(-)-n-p-Tosyl-1,2-Diphenylethylenediamine
CAS No.	144222-34-4
Molecular Formula	C28H28N2O2S
Molecular Weight	456.60 g/mol
Synonyms	(1R,2R)-(-)-1,2-Diphenyl-N-(p-toluenesulfonyl)ethylenediamine; (1R,2R)-(-)-N-(p-Toluenesulfonyl)-1,2-diphenylethylenediamine; (R,R)-TsDPEN; (R,R)-(-)-N-(p-Tolylsulfonyl)-1,2-diphenylethylenediamine; (1R,2R)-N-(4-Methylphenyl)sulfonyl-1,2-diphenylethane-1,2-diamine; (R,R)-N-(p-Toluenesulfonyl)-1,2-diphenylethylenediamine; (1R,2R)-Ts-DPEN; (R,R)-Ts-DPEN
EINECS	Contact for details

Quality Control

Our (1R,2R)-(-)-n-p-Tosyl-1,2-Diphenylethylenediamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chiral purity and chemical integrity, meeting the stringent requirements for pharmaceutical and advanced synthetic applications. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	168 - 172 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.