Description

Guanosine-5'-o-(S-(3-Bromo-2-Oxopropyl))Thiophosphate is a chemically modified nucleotide analog, specifically a thiophosphate derivative of guanosine, designed for advanced biochemical research and pharmaceutical development. This compound serves as a critical building block and a versatile chemical probe for studying enzyme mechanisms, particularly those involving kinases and other phosphotransferases. It is primarily utilized by research institutions and pharmaceutical companies engaged in nucleotide chemistry, enzymology, and the development of novel therapeutic agents targeting cellular signaling pathways.

Application

• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies to investigate the activity and kinetics of protein kinases, GTPases, and other phosphotransfer enzymes.
• Proteomics & Chemical Biology: Used as an affinity probe or labeling reagent for the identification and isolation of nucleotide-binding proteins and enzymes.
• Pharmaceutical Development: Serves as a key intermediate in the synthesis of novel nucleotide-based prodrugs, antiviral agents, or targeted cancer therapies.
• Mechanistic Studies: Employed to elucidate reaction mechanisms and transition-state structures in phosphoryl transfer reactions due to its thiophosphate moiety.
• Diagnostic Reagent Synthesis: Potential use in creating labeled nucleotides for diagnostic assays and imaging techniques.

Basic Information

Product Name	Guanosine-5'-o-(S-(3-Bromo-2-Oxopropyl))Thiophosphate
CAS No.	144085-39-2
Molecular Formula	C13H18BrN5O8PS
Molecular Weight	522.25 g/mol
Synonyms	3-Bromo-2-oxopropyl guanosine-5'-thiophosphate; Guanosine 5'-[S-(3-bromo-2-oxopropyl)]thiophosphate; 5'-O-[S-(3-Bromo-2-oxopropyl)]thiophosphoguanosine; BrOP-GTPγS (common abbreviation); GTPγS-(3-Br-2-oxopropyl) ester; Thiophosphoryl guanosine bromoacetone derivative; CAS 144085-39-2
EINECS	Contact for details

Quality Control

Our Guanosine-5'-o-(S-(3-Bromo-2-Oxopropyl))Thiophosphate is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider under an inert atmosphere to maintain stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.